咪唑安定复合地佐辛在腹腔镜阑尾切除术中的效果评估

doi:10.5246/jcps.2023.03.018

中国药学(英文版) ›› 2023, Vol. 32 ›› Issue (3): 207-213.DOI: 10.5246/jcps.2023.03.018

• 【药事管理与临床药学专栏】 • 上一篇下一篇

咪唑安定复合地佐辛在腹腔镜阑尾切除术中的效果评估

蔺长平¹^,^*(), 汪三岳¹, 薛允国², 俞游柳³

1. 建德市第一人民医院麻醉科, 浙江建德 311600
2. 黑龙江省鸡西市人民医院麻醉科, 黑龙江鸡西 158100
3. 绍兴市上虞中医医院麻醉科, 浙江绍兴 312300

收稿日期:2022-09-25 修回日期:2022-10-29 接受日期:2022-11-26 出版日期:2023-03-31 发布日期:2023-03-30
通讯作者: 蔺长平
作者简介:
+ Tel.: +86-13968047460, E-mail: Weijiuhif@163.com

The effects of midazolam combined with dezocine on laparoscopic appendectomy

Changping Lin¹^,^*(), Sanyue Wang¹, Yunguo Xue², Youliu Yu³

1 Department of Anesthesiology, the First People’s Hospital of Jiande City, Jiande 311600, Zhejiang, China
2 Department of Anesthesiology, People’s Hospital of Jixi City, Heilongjiang Province, Jixi 158100, Heilongjiang, China
3 Department of Anesthesiology, Shangyu Hospital of Traditional Chinese Medicine, Shaoxing City, Shaoxing 312300, Zhejiang, China

Received:2022-09-25 Revised:2022-10-29 Accepted:2022-11-26 Online:2023-03-31 Published:2023-03-30
Contact: Changping Lin

摘要/Abstract

摘要：

本文主要探讨咪唑安定复合地佐辛在腹腔镜阑尾切除术前麻醉诱导中的应用效果。将我院2018年6月–2021年3月107例阑尾炎患者随机分为对照组(53例)和观察组(54例), 其中对照组给予咪唑安定, 观察组给予咪唑安定复合地佐辛, 并比较两组生命体征、镇痛、镇静指标及不良反应发生情况。结果发现, 与T0时间点相比, 两组HR、MAP在T1、T2、T3、T4点均降低(P < 0.05), 但两组内T1–T4之间各自变化不明显(P > 0.05); 观察组MAP在T1–T4时间点时与对照组相比均降低(P < 0.05)。SPO₂在各时间点均无明显变化(P > 0.05)。术后6 h NRS评分提示, 观察组(3.52 ± 1.28分)明显低于对照组(4.26 ± 1.76分, P < 0.05); 术后1 h Ramsay镇静评分提示, 观察组(2.32 ± 0.78分)明显高于对照组(1.73 ± 0.65分, P < 0.05)。不良反应发生率观察组(7.4%)与对照组(11.3%)相比无明显差异(P > 0.05)。由此可得, 咪唑安定复合地佐辛能够更好地降低腹腔镜阑尾切除术患者术后MAP及术后疼痛, 且患者术后镇静效果好, 具有一定安全性。

关键词: 腹腔镜阑尾炎, 咪唑安定, 地佐辛, 效果, 安全性

Abstract:

In the present study, we aimed to investigate the effect of midazolam combined with dezocine on anesthesia induction before laparoscopic appendectomy. A total of 107 patients with appendicitis in our hospital from June 2018 to March 2021 were randomly divided into the control group (53 cases) and the observation group (54 cases). The control group was given midazolam, and the observation group was given midazolam combined with dezocine. The vitals, analgesia, sedation indexes, and adverse reactions of the two groups were compared. Compared with time T0, HR and MAP at T1, T2, T3, and T4 in both groups were decreased (P < 0.05), while there was no significant change in T1–T4 in the two groups, respectively (P > 0.05). MAP of the observation group was lower than that of the control group at the T1–T4 time points (P < 0.05). SPO₂ showed no significant change at all time points (P > 0.05). The NRS score at 6 h after surgery of the observation group (3.52 ± 1.28 scores) was significantly lower compared with the control group (4.26 ± 1.76 scores, P < 0.05). The Ramsay sedation score at 1 h after surgery of the observation group (2.32 ± 0.78 scores) was significantly higher compared with the control group (1.73 ± 0.65 scores, P < 0.05). Moreover, there was no significant difference in the incidence of adverse reactions between the observation group (7.4%) and the control group (11.3%, P > 0.05). Collectively, midazolam combined with dezocine could better reduce postoperative MAP and postoperative pain in patients with laparoscopic appendectomy, showing good postoperative sedation effect and safety.

Key words: Laparoscopic appendicitis, Midazolam, Dezocine, Effect, Safety

Supporting:

蔺长平, 汪三岳, 薛允国, 俞游柳. 咪唑安定复合地佐辛在腹腔镜阑尾切除术中的效果评估[J]. 中国药学(英文版), 2023, 32(3): 207-213.

Changping Lin, Sanyue Wang, Yunguo Xue, Youliu Yu. The effects of midazolam combined with dezocine on laparoscopic appendectomy[J]. Journal of Chinese Pharmaceutical Sciences, 2023, 32(3): 207-213.

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参考文献 15

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咪唑安定复合地佐辛在腹腔镜阑尾切除术中的效果评估

The effects of midazolam combined with dezocine on laparoscopic appendectomy

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