麦冬多糖-铁(III)配合物在水溶液和固态条件下的自组装

doi:10.5246/jcps.2019.09.063

中国药学(英文版) ›› 2019, Vol. 28 ›› Issue (9): 665-672.DOI: 10.5246/jcps.2019.09.063

• 【研究论文】 • 上一篇

麦冬多糖-铁(III)配合物在水溶液和固态条件下的自组装

谈春霞^1*, 王亚丽²

1. 甘肃中医药大学, 甘肃兰州 730000
2. 甘肃中医药大学, 甘肃省中药质量与标准研究重点实验室, 甘肃兰州 730000

收稿日期:2019-05-27 修回日期:2019-06-13 出版日期:2019-09-30 发布日期:2019-08-15
通讯作者: Tel.: +86-13519641096, E-mail: tancx@sina.com
基金资助:
Key Laboratory of Traditional Chinese Medicine Quality and Standard, Gansu University of Chinese Medicine, Lanzhou, China (Grant No. ZYZL18-006).

Self-assembly of Ophiopogonis polysaccharide-iron (III) complex in aqueous solution and solid state

Chunxia Tan^1*, Yali Wang²

1. Gansu University of Chinese Medicine, Lanzhou 730000, China
2. Key Laboratory of Traditional Chinese Medicine Quality and Standard, Gansu University of Chinese Medicine, Lanzhou 730000, China

Received:2019-05-27 Revised:2019-06-13 Online:2019-09-30 Published:2019-08-15
Contact: Tel.: +86-13519641096, E-mail: tancx@sina.com
Supported by:
Key Laboratory of Traditional Chinese Medicine Quality and Standard, Gansu University of Chinese Medicine, Lanzhou, China (Grant No. ZYZL18-006).

摘要/Abstract

摘要：

本文制备并表征了麦冬多糖-铁(III)(OPI)并获得了制备OPJ的最佳条件: OP和柠檬酸三钠的质量比为4:1;在pH 8.0–8.5的水溶剂环境中反应3小时。反应过程中始终保持反应温度为70°C。通过扫描电子显微镜,透射电子显微镜和小角度X射线衍射分别研究了在水溶液和固态中OPI的聚集形态或结构。在水溶液中, OPI可以自组装成具有花状形貌的微囊泡。X射线衍射结果显示OPI具有层状结构。结合实验结果,我们针对OPI在水溶液和固态条件下的自组装提出了核-壳模型。

关键词: 超分子复合物, 麦冬多糖-铁(III), 自组装, 花状形貌, 层状结构

Abstract:

Ophiopogonis polysaccharide-iron (III) (OPI) was prepared and characterized in the present study. The optimum condition for preparing OPI was as follows: OP and trisodium citrate were mixed at a weight ratio of 4:1 and reacted in a water bath at 70 °C for 3 h within the pH range of 8.0–8.5. Aggregation morphology or structure of OPI in aqueous solution and solid state was studied by scanning electron microscopy, transmission electron microscopy and small-angle X-ray diffraction. In aqueous solution, OPI could self-assemble into micron vesicles with flower-shaped morphology. Results of X-ray diffraction showed OPI with layered structure. A core-shell model was proposed for OPI.

Key words: Supramolecular complexes, Ophiopogonis polysaccharide-iron (III), Self-assembly, Flower-shaped morphology, Layered structure

中图分类号:

Supporting:

谈春霞, 王亚丽. 麦冬多糖-铁(III)配合物在水溶液和固态条件下的自组装[J]. 中国药学(英文版), 2019, 28(9): 665-672.

Chunxia Tan, Yali Wang. Self-assembly of Ophiopogonis polysaccharide-iron (III) complex in aqueous solution and solid state[J]. Journal of Chinese Pharmaceutical Sciences, 2019, 28(9): 665-672.

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麦冬多糖-铁(III)配合物在水溶液和固态条件下的自组装

Self-assembly of Ophiopogonis polysaccharide-iron (III) complex in aqueous solution and solid state

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