Cistus parviflorus叶化学成分研究

doi:10.5246/jcps.2018.01.005

摘要/Abstract

摘要：

研究Cistus parviflorus叶的化学成分。采用溶剂提取和色谱分离技术进行化学成分分离,根据质谱和波谱数据鉴定化合物结构。从Cistus parviflorus叶提取物中分离得到18个化合物,分别鉴定为山奈酚3-O-(3′′,6′′-双-O-E-p-香豆酰基)-β-D-吡喃葡萄糖苷(1), 东莨菪素(2), 山奈酚3-O-(3′′-O-E-p-香豆酰基)-β-D-吡喃葡萄糖苷(3), 3-O-(6′′-O-E-p-香豆酰基)-β-D-吡喃葡萄糖苷(4), 3-O-β-D-吡喃葡萄糖苷(5), 山奈酚3-O-α-L-吡喃鼠李糖基-(1→2)-(6′′-O-E-p-香豆酰基)-β-D-吡喃葡萄糖苷(6), methyl flavogallonate (7), 槲皮素3-O-β-D-吡喃葡萄糖苷(8), 槲皮素3-O-β-D-吡喃半乳糖苷(9), 对苯二酚(10),熊果素(11), 甲基β-吡喃葡萄糖(12), 莽草酸(13), (S)-1,2-丙二醇-1-O-β-D-吡喃葡萄糖苷(14), 苯甲基-O-α-L-吡喃鼠李糖基-(1→6)-β-D-吡喃葡萄糖苷(15), 2-苯乙基-O-α-L-吡喃鼠李糖基-(1→6)-β-D-吡喃葡萄糖苷(16), corchoionoside C(17), 山奈酚3-O-α-L-吡喃鼠李糖基-(1→2)-β-D-吡喃葡萄糖苷(18)。化合物1~2, 6~7, 10~12和14~16为首次从Cistus属中分离得到。

关键词: 半日花科, Cistus parviflorus, 黄酮醇, 糖苷

Abstract:

A phytochemical investigation on the leaves of Cistus parviflorus led to the isolation of 18 compounds. The structures of the isolated compounds were elucidated as kaempferol 3-O-(3′′,6′′-di-O-E-p-coumaroyl)-β-D-glucopyranoside (1), scopoletin (2),kaempferol 3-O-(3′′-O-E-p-coumaroyl)-β-D-glucopyranoside (3), kaempferol 3-O-(6′′-O-E-p-coumaroyl)-β-D-glucopyranoside (4), kaempferol 3-O-β-D-glucopyranoside (5), kaempferol 3-O-α-L-rhamnopyranosyl-(1→2)-(6′′-O-E-p-coumaroyl)-β-D-glucopyranoside (6), methyl flavogallonate(7), quercetin 3-O-β-D-glucopyranoside (8), quercetin 3-O-β-D-galactopyranoside (9), hydroquinone (10), arbutin (11), methyl β-glucopyranoside (12), shikimic acid (13), (S)-1,2-propandiol-1-O-β-D-glucopyranoside (14), benzyl-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside (15), 2-phenethyl-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside (16), corchoionoside C (17), kaempferol 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside (18) by the analysis of the MS and NMR spectroscopic data and comparison with the literature. Compounds 1–2, 6–7, 10–12, and 14–16 were isolated from Cistus genus for the first time.

Key words: Cistaceae, Cistus parviflorus, Flavonols, Glycosides

中图分类号:

R284

Supporting:

房芯羽, 王蓉蓉, 孙世伟, 刘晓晓, 刘小红, 王炜, 岡田嘉仁, 王威. Cistus parviflorus叶化学成分研究[J]. 中国药学(英文版), 2018, 27(1): 40-50.

Xinyu Fang, Rongrong Wang, Shiwei Sun, Xiaoxiao Liu, Xiaohong Liu, Wei Wang, Yoshihito Okada, Wei Wang. Chemical constituents from the leaves of Cistus parviflorus[J]. Journal of Chinese Pharmaceutical Sciences, 2018, 27(1): 40-50.

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