Synthesis and characterization of pyrimidines analogues as anti-Alzheimer’s agents

doi:10.5246/jcps.2017.11.094

中国药学(英文版) ›› 2017, Vol. 26 ›› Issue (11): 834-846.DOI: 10.5246/jcps.2017.11.094

Synthesis and characterization of pyrimidines analogues as anti-Alzheimer’s agents

Yadav Rakesh^*, Maan Monika, Yadav Divya

Department of Pharmacy, Banasthali University, Banasthali-304022 Rajasthan, India

收稿日期:2017-05-17 修回日期:2017-06-19 出版日期:2017-11-30 发布日期:2017-09-28
通讯作者: Tel.: +91-96-948-91228, E-mail: rakesh_pu@yahoo.co.in

Synthesis and characterization of pyrimidines analogues as anti-Alzheimer’s agents

Yadav Rakesh^*, Maan Monika, Yadav Divya

Department of Pharmacy, Banasthali University, Banasthali-304022 Rajasthan, India

Received:2017-05-17 Revised:2017-06-19 Online:2017-11-30 Published:2017-09-28
Contact: Tel.: +91-96-948-91228, E-mail: rakesh_pu@yahoo.co.in

摘要/Abstract

摘要：

Pyrimidine derivatives have been reported as neuroprotective agents useful for the treatment of various neurodegenerativedisorders. In the present study, several pyrimidine analogues have been evaluated as neuroprotective agents in Morris water maze model. It was observed that pyrimidine derivatives 8–17 considerably improve learning, memory, and movement deficits in animal models. Biochemical estimations of brain serum of treated animals revealed suppression of oxidative and nitrosative stress, acetylcholinesterase activity, and other parameters which leads to neurodegeneration of brain. Of all the pyrimidine derivatives, thiomorpholine derivative 8 and piperazine ethanol derivative 17 were found to be the most active neuroprotective agents and produced effects comparable to standard drug rivastigmine in terms of behavioral, biochemical, and molecular aspects.

关键词: Alzheimer’s disease, Neurodegeneration, Pyrimidine derivatives, Biochemical tests

Abstract:

Key words: Alzheimer’s disease, Neurodegeneration, Pyrimidine derivatives, Biochemical tests

中图分类号:

R916

Supporting:

Yadav Rakesh, Maan Monika, Yadav Divya. Synthesis and characterization of pyrimidines analogues as anti-Alzheimer’s agents[J]. 中国药学(英文版), 2017, 26(11): 834-846.

Yadav Rakesh, Maan Monika, Yadav Divya. Synthesis and characterization of pyrimidines analogues as anti-Alzheimer’s agents[J]. Journal of Chinese Pharmaceutical Sciences, 2017, 26(11): 834-846.

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Synthesis and characterization of pyrimidines analogues as anti-Alzheimer’s agents

Synthesis and characterization of pyrimidines analogues as anti-Alzheimer’s agents

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