腺梗豨莶中一个新二萜类化合物的分离与结构解析

doi:10.5246/jcps.2013.02.028

腺梗豨莶中一个新二萜类化合物的分离与结构解析

谢可辉, 王建斌, 杨蓉, 吴琼, 皮晓雪, 付宏征^*

1. 北京大学医学部天然药物及仿生药物国家重点实验室, 北京 100191
2. 扬州大学药学院, 江苏扬州 225009

收稿日期:2012-11-28 修回日期:2013-01-22 出版日期:2013-03-18 发布日期:2013-03-18
通讯作者: 付宏征*

A new ent-pimarane diterpenoid from Siegesbeckia pubescens

Kehui Xie, Jianbin Wang, Rong Yang, Qiong Wu, Xiaoxue Pi, Hongzheng Fu^*

1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Science, Peking University Health Science Center, Beijing 100191, China
2. Department of Pharmaceutics, School of Medical Academy, Yangzhou University, Yangzhou 225009, China

Received:2012-11-28 Revised:2013-01-22 Online:2013-03-18 Published:2013-03-18
Contact: Hongzheng Fu*

摘要/Abstract

摘要：

从腺梗豨莶中分离得到一个新的 ent-pimarane 型二萜类化合物 ent-16-nor-3-oxo-pimar-8(14)-en-15-al (1), 以及4个已知二萜类化合物 kirenol (2), ent-2-oxo-15,16,19-trihydroxypimar-8(14)-ene (3), darutigenol (4), darutoside (5)。化合物1的平面结构及相对构型通过波谱学方法确定。

关键词: 腺梗豨莶, 二萜, 结构解析

Abstract:

One new ent-pimarane diterpenoid ent-16-nor-3-oxo-pimar-8(14)-en-15-al (1) together with four known diterpenoids kirenol (2), ent-2-oxo-15,16,19-trihydroxypimar-8(14)-ene (3), darutigenol (4) and darutoside (5) were isolated from the ethanol extract of Siegesbeckia pubescens. The planar structures and relative configurations of these compounds were elucidated by comprehensive spectroscopic analysis.

Key words: Siegesbeckia pubescens, Diterpenoids, Structural identification

中图分类号:

R284

Supporting: Foundation items: National Natural Science Foundation of China (Grant No. 30973628) and the National Science and Technology Project of China (Grant No. 2012ZX09103201-022).
^*Corresponding author. Tel.: 86-10-82805212

谢可辉, 王建斌, 杨蓉, 吴琼, 皮晓雪, 付宏征^*. 腺梗豨莶中一个新二萜类化合物的分离与结构解析[J]. , DOI: 10.5246/jcps.2013.02.028.

Kehui Xie, Jianbin Wang, Rong Yang, Qiong Wu, Xiaoxue Pi, Hongzheng Fu^*. A new ent-pimarane diterpenoid from Siegesbeckia pubescens[J]. , DOI: 10.5246/jcps.2013.02.028.

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