天门冬中的两个新呋甾皂苷aspacochinoside L和aspacochinoside M

doi:10.5246/jcps.2013.02.029

• 【研究论文】 • 上一篇

天门冬中的两个新呋甾皂苷aspacochinoside L和aspacochinoside M

简锐, 李军, 曾克武, 李宁, 姜勇, 屠鹏飞^*

1. 北京大学医学部药学院天然药物及仿生药物国家重点实验室, 北京 100191
2. 北京中医药大学中药现代研究中心, 北京 100029

收稿日期:2012-10-21 修回日期:2013-01-08 出版日期:2013-03-18 发布日期:2013-03-18
通讯作者: 屠鹏飞*

Two new furostanol glycosides from Asparagus cochinchinensis (Lour.) Merr.

Rui Jian, Jun Li, Kewu Zeng, Ning Li, Yong Jiang, Pengfei Tu^*

1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China
2. Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China

Received:2012-10-21 Revised:2013-01-08 Online:2013-03-18 Published:2013-03-18
Contact: Pengfei Tu*

摘要/Abstract

摘要：

从天门冬的根中分离得到两个新呋甾烷型皂苷aspacochinoside L (1)和aspacochinoside M (2), 通过化学和波谱学方法确定了化合物1和2的结构。利用脂多糖(LPS)诱导的小胶质细胞(BV-2)炎症模型, 测试了化合物的抗炎活性, 其中aspacochinoside M的IC50值为32.26 μM。

关键词: 天门冬, 甾体皂苷, 呋甾皂苷, 阿斯帕苷

Abstract:

Two new furostanol glycosides, aspacochinosides L (1) and M (2), were isolated from the roots of Asparagus cochinchinensis (Lour.) Merr. Their structures were determined by chemical methods and NMR spectral analysis, including extensive 1D and 2D NMR experiments. Compounds 1 and 2 were investigated for their anti-neuroinflammatory activity in LPS-induced BV-2 cells. Compound 2 showed moderate inhibitory effect on NO production in LPS-induced BV-2 microglial cells with IC50 value of 32.26 μM.

Key words: Asparagus cochinchinensis, Steroidal saponin, Furostanol glycoside, Aspacochinoside

中图分类号:

R284

Supporting: Foundation items: National Key Technology R&D Program “New Drug Innovation” of China (Grant No. 2012ZX09301002-002-002 and 2012ZX09304-005).
^*Corresponding author. Tel./Fax: 86-10-82802750

简锐, 李军, 曾克武, 李宁, 姜勇, 屠鹏飞^*. 天门冬中的两个新呋甾皂苷aspacochinoside L和aspacochinoside M[J]. , DOI: 10.5246/jcps.2013.02.029.

Rui Jian, Jun Li, Kewu Zeng, Ning Li, Yong Jiang, Pengfei Tu^*. Two new furostanol glycosides from Asparagus cochinchinensis (Lour.) Merr.[J]. , DOI: 10.5246/jcps.2013.02.029.

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天门冬中的两个新呋甾皂苷aspacochinoside L和aspacochinoside M

Two new furostanol glycosides from Asparagus cochinchinensis (Lour.) Merr.

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