细胞膜色谱法及其在中药活性成分分析中的应用

doi:10.5246/jcps.2011.01.002

摘要/Abstract

摘要：

中药经过了长期的临床试验, 具有可靠的治疗效果, 并为新药开发提供极好的活性化合物库, 已逐渐得到全球范围内的广泛关注。中药中通常含有成百上千的化学物质, 但其中只有少数的化合物具有药理作用, 而其余大多数成分的存在使得分析和筛选中药的活性成分非常困难。因此, 探寻用于分析和筛选中药活性成分的策略是中药研究中长期关注的问题, 细胞膜色谱法已成为研究中药活性成分的有效方法。本文将概述细胞膜色谱法的原理、特点、应用前景及其在中药研究中可能面临的问题, 细胞膜色谱法在中药活性成分分析和筛选中的作用将日益突出。

关键词: 细胞膜, 细胞膜色谱法, 筛选, 活性成分, 中药

Abstract:

Traditional Chinese medicines (TCMs) have a long history of clinical testing and reliable therapeutic efficacy. They have attracted international attention as excellent sources of bioactive compounds for the discovery of new drugs. However, TCMs usually contain hundreds or even thousands of components and only a few of these compounds are responsible for the pharmacological effects. The large number of components in TCMs makes the analysis and screening for bioactive compounds extremely difficult. Therefore, strategies for analysis and screening of bioactive compounds in TCMs have long been a focus of studies on TCMs. Cell membrane chromatography (CMC) has become a useful tool for studying the bioactive compounds of TCMs. This review summarizes the principles, characteristics, and application of CMC, and the possible problems faced when working with TCMs. This method will likely become increasingly important for screening and analysis of bioactive compounds in TCMs.

Key words: Cell membrane, Cell membrane chromatography, Screening, Bioactive ingredients, Traditional Chinese medicines

中图分类号:

R284

Supporting:

Foundation item: Scientific and Technological Innovation Project Foundation of Shanxi China (Grant No. 20090321099).
^*Corresponding author. Tel.: 86-351-4690114; fax: 86-351-4690114

杨兴鑫, 张艳利, 张晓霞, 李晓妮^*. 细胞膜色谱法及其在中药活性成分分析中的应用[J]. , DOI: 10.5246/jcps.2011.01.002.

Xing-Xin Yang, Yan-Li Zhang, Xiao-Xia Zhang, Xiao-Ni Li^*. Cell membrane chromatography and its application in the analysis of
bioactive ingredients of TCMs [J]. , DOI: 10.5246/jcps.2011.01.002.

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