药师主导的老年患者干预研究: 一项文献计量学分析

doi:10.5246/jcps.2024.08.056

摘要/Abstract

摘要：

药师主导的干预措施对老年患者有显著获益, 且已有大量相关研究发表。本文基于文献计量学方法分析该领域的相关研究, 从而了解相关研究的现状和热点前沿。检索在Web of Science Core Collection数据库发表的相关研究, 时间为建库至2022年9月8日, 然后利用VOSviewer和CiteSpace软件进行文献计量学分析。共纳入相关文献6084篇, 其中 "Article" 5496篇(90.34%), 年度发文量呈上升趋势。相关研究在120个国家/地区开展, 其中美国在该领域的贡献最大, 发文量最多(n = 2637); 悉尼大学发表的论文最多(n = 155); 发文量最多的是悉尼大学的学者Timothy F Chen (n = 35), 共被引频次最多的是费城科学大学的学者Joseph T Hanlon; Journal of Managed Care & Specialty Pharmacy和Journal of the American Geriatrics Society分别在最高产期刊(n = 251)和共被引期刊(n = 5293)中排名第一。该领域的热点话题包括新标准的制定、现有标准的更新、老年人潜在不适当用药标准的使用、对老年人不适当多重用药的关注, 以及对药师主导的干预措施在老年人群中积极作用的评估。这项文献计量学分析提供了药师主导的老年患者干预措施的全面概述, 有助于了解过去30年该领域的发展。

关键词: 文献计量学, 药师主导干预, 老年人, VOSviewer, CiteSpace

Abstract:

Pharmacist-led interventions have demonstrated significant benefits for older adults, with a plethora of studies dedicated to this subject. A bibliometric study was conducted to assess the current state of research and summarize key themes in the domain of pharmacist-led interventions for older adults. The analysis encompassed publications available in the Web of Science Core Collection from its inception until September 8, 2022. To perform the bibliometric analysis, VOSviewer and CiteSpace software were employed. The initial query yielded a substantial 6 084 relevant documents spanning the period from 1995 to September 8, 2022. Of these, 5496 (constituting 90.34%) were categorized as "Article". Notably, the yearly output of publications displayed an upward trajectory. This body of work emanated from 120 countries and regions, with the United States being the foremost contributor, accounting for the majority of publications (n = 2637). The University of Sydney in Australia emerged as the institution with the highest number of publications (n = 155). Timothy F Chen, affiliated with the University of Sydney, was the most prolific author, boasting 35 publications. Joseph T Hanlon, a scholar affiliated with the University of the Sciences in Philadelphia, emerged as the most frequently co-cited author. When considering journal productivity, The Journal of Managed Care & Specialty Pharmacy stood out as the most prolific journal (n = 251). Conversely, the Journal of the American Geriatrics Society garnered the highest number of co-citations (n = 5293). The predominant research themes encompassed the development of new criteria, updates to existing criteria, the utilization of criteria for identifying potentially inappropriate medications in older populations, concerns surrounding inappropriate polypharmacy in this demographic, and the evaluation of the positive impact of pharmacist-led interventions for older adults. In conclusion, this comprehensive bibliometric analysis offers a panoramic view of pharmacist-led interventions for older adults, providing valuable insights into the field’s evolution over the past three decades.

Key words: Bibliometrics, Pharmacist-led interventions, Older adults, VOSviewer, CiteSpace

Supporting:

卢晓静, 贾雪冬, 司方莹, 杨晰, 张婉, 尹钊. 药师主导的老年患者干预研究: 一项文献计量学分析[J]. 中国药学(英文版), 2024, 33(8): 751-765.

Xiaojing Lu, Xuedong Jia, Fangying Si, Xi Yang, Wan Zhang, Zhao Yin. Pharmacist-led interventions in older adults: A bibliometric analysis of scientific literature[J]. Journal of Chinese Pharmaceutical Sciences, 2024, 33(8): 751-765.

图/表 11

Figure 1. Annual growth of publications in the field of pharmacist-led interventions in older adults.

Table 1. Top 10 prolific countries/regions in studies on pharmacist-led interventions in older adults.

Figure 2. The network map of countries (T = 66) in the field of pharmacist-led interventions in older adults.

Table 2. Top 10 prolific institutions in research on pharmacist-led interventions in older adults.

Figure 3. The network map of institutions (T = 59) in the field of pharmacist-led interventions in older adults.

Table 3. Highly influential authors in the field of pharmacist-led interventions in older adults.

Figure 4. The network map of authors (T = 16) in the field of pharmacist-led interventions in older adults.

Table 4. The 10 most active journals and co-cited journals that published articles in the field of pharmacist-led interventions in older adults.

Figure 5. The network map of academic journals (A, T = 27) and co-cited academic journals (B, T= 1606) in the field of pharmacist-led interventions in older adults.

Table 5. The top 10 co-cited references in the field of pharmacist-led interventions in older adults.

Figure 6. The references with strong citation bursts (MD = 2) in articles in the field of pharmacist-led interventions in older adults.

参考文献 34

[1]	World population prospects 2022. Available online: https://www.un.org/development/desa/pd/zh/content/World-Population-Prospects-2022 (accessed on October 9 2022).
[2]	Rodrigues, A.R.; Teixeira-Lemos, E.; Mascarenhas-Melo, F.; Lemos, L.P.; Bell, V. Pharmacist intervention in Portuguese older adult care. Healthcare (Basel). 2022, 10, 1833.
[3]	Tang, J.; Wang, K.; Yang, K.; Jiang, D.C.; Fang, X.H.; Su, S.; Lin, Y.; Chen, S.C.; Gu, H.Y.; Li, P.M.; Yan, S.Y. A combination of Beers and STOPP criteria better detects potentially inappropriate medications use among older hospitalized patients with chronic diseases and polypharmacy: a multicenter cross-sectional study. BMC Geriatr. 2023, 23, 44.
[4]	World Health Organization (WHO). WHO Launches Global Effort to Halve Medication-Related Errors in 5 Years. Available online: https://www.who.int/news/item/29-03-2017-who-launches-global-effort-to-halve-medication-related-errors-in-5-years (accessed on October 9 2022).
[5]	Policarpo, V.; Romano, S.; António, J.H.C.; Correia, T.S.; Costa, S. A new model for pharmacies? Insights from a quantitative study regarding the public’s perceptions. BMC Health Serv. Res. 2019, 19, 186.
[6]	Sheraz, A.; Salahudeen Mohammed, S.; Bereznicki Luke, R.E.; Curtain Colin, M. Pharmacist-led interventions to reduce adverse drug events in older people living in residential aged care facilities: a systematic review. Br. J. Clin. Pharmacol. 2021, 87, 3672–3689.
[7]	Faton, G.; Drubay, P.A.; Vergez, G.; Faure, S. Impact of pharmacist-led shared medication reviews on adherence among polymedicated older patients: an observational retrospective French study. J. Am. Pharm. Assoc (2003). 2022, 62, 150–156.e1.
[8]	Feng, S.Y.; Chen, P.J.; Wang, N.; Zhao, B. Lu, Y.F.; Zhang, Y.H. Exploration of collaborative drug therapy management mode for elderly patients with chronic diseases. J. Chin. Pharm. Sci. 2022, 31, 866–876.
[9]	Martin, P.; Tamblyn, R.; Benedetti, A.; Ahmed, S.; Tannenbaum, C. Effect of a pharmacist-led educational intervention on inappropriate medication prescriptions in older adults: the D-PRESCRIBE randomized clinical trial. JAMA. 2018, 320, 1889–1898.
[10]	Tarn, D.M.; Paterniti, D.A.; Wenger, N.S.; Williams, B.R.; Chewning, B.A. Older patient, physician and pharmacist perspectives about community pharmacists’ roles. Int. J. Pharm. Pract. 2012, 20, 285–293.
[11]	Yeh, C.H.; Chien, T.W.; Chou, P.H. Citation analysis of the 100 top-cited articles on discectomy via endoscopy since 2011 using alluvial diagrams: bibliometric analysis. Eur. J. Med. Res. 2022, 27, 169.
[12]	Chen, C.M. Searching for intellectual turning points: progressive knowledge domain visualization. Proc. Natl. Acad. Sci. USA. 2004, 101, 5303–5310
[13]	Marcum, Z.; Jiang, S.Q.; Bacci, J.; Ruppar, T. Pharmacist-led interventions to improve medication adherence in older adults: a meta-analysis. J. Am. Geriatr. Soc. 2021, 69, 3301–3311.
[14]	van Eck, N.J.; Waltman, L. Software survey: VOSviewer, a computer program for bibliometric mapping. Scientometrics. 2010, 84, 523–538.
[15]	Hou, J.H.; Yang, X.C.; Chen, C.M. Emerging trends and new developments in information science: a document co-citation analysis (2009-2016). Scientometrics. 2018, 115, 869–892.
[16]	Hepler, C.D.; Grainger-Rousseau, T.J. Pharmaceutical care versus traditional drug treatment. Drugs. 1995, 49, 1–10.
[17]	Lu, X.J.; Lu, C.C.; Yang, Y.J.; Shi, X.F.; Wang, H.B.; Yang, N.; Yang, K.H.; Zhang, X.J. Current status and trends in peptide receptor radionuclide therapy in the past 20 years (2000–2019): a bibliometric study. Front. Pharmacol. 2021, 12, 624534.
[18]	Fick, D.M.; Cooper, J.W.; Wade, W.E.; Waller, J.L.; Maclean, J.R.; Beers, M.H. Updating the Beers criteria for potentially inappropriate medication use in older adults: results of a US consensus panel of experts. Arch. Int. Med. 2003, 163, 2716–2724.
[19]	By the American Geriatrics Society 2012 Beers Criteria Update Expert Panel. American geriatrics society 2015 updated beers criteria for potentially inappropriate medication use in older adults. J. Am. Geriatr. Soc. 2015, 63, 2227–2246.
[20]	O’Mahony, D.; O'Sullivan, D.; Byrne, S.; O'Connor, M.N.; Ryan, C.; Gallagher, P. STOPP/START criteria for potentially inappropriate prescribing in older people: version 2. Age Ageing. 2015, 44, 213–218.
[21]	By the American Geriatrics Society 2015 Beers Criteria Update Expert Panel. American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in older adults. J. Am. Geriatr. Soc. 2012, 60, 616–631.
[22]	Beers, M.H.; Ouslander, J.G.; Rollingher, I.; Reuben, D.B.; Brooks, J.; Beck, J.C. Explicit criteria for determining inappropriate medication use in nursing home residents. UCLA Division of Geriatric Medicine. Arch. Int. Med. 1991, 151, 1825–1832.
[23]	Beers, M.H. Explicit criteria for determining potentially inappropriate medication use by the elderly. An update. Arch. Int. Med. 1997, 157, 1531–1536.
[24]	Griebling, T. Re: American geriatrics society 2019 updated AGS beers criteria® for potentially inappropriate medication use in older adults. J. Am. Geriatr. Soc. 2019, 67, 674–694.
[25]	Gallagher, P.; Ryan, C.; Byrne, S.; Kennedy, J.; O’Mahony, D. STOPP (Screening Tool of Older Person’s Prescriptions) and START (Screening Tool to Alert doctors to Right Treatment). Consensus validation. Int. J. Clin. Pharmacol. Ther. 2008, 46, 72–83.
[26]	Anrys, P.M.S.; Strauven, G.C.; Foulon, V.; Degryse, J.M.; Henrard, S.; Spinewine, A. Potentially inappropriate prescribing in Belgian nursing homes: prevalence and associated factors. J. Am. Med. Dir. Assoc. 2018, 19, 884–890.
[27]	Charlson, M.E.; Pompei, P.; Ales, K.L.; MacKenzie, C.R. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J. Chronic. Dis. 1987, 40, 373–383.
[28]	Spinewine, A.; Schmader, K.E.; Barber, N.; Hughes, C.; Lapane, K.L.; Swine, C.; Hanlon, J.T. Appropriate prescribing in elderly people: how well can it be measured and optimised? Lancet. 2007, 370, 173–184.
[29]	Hepler, C.D.; Strand, L.M. Opportunities and responsibilities in pharmaceutical care. Am. J. Hosp. Pharm. 1990, 47, 533–543.
[30]	Osterberg, L.; Blaschke, T. Adherence to medication. N. Engl. J. Med. 2005, 353, 487–497.
[31]	Chen, C.M.; Dubin, R.; Kim, M.C. Orphan drugs and rare diseases: a scientometric review (2000–2014). Expert. Opin. Orphan. Drugs. 2014, 2, 709–724.
[32]	Scott, I.A.; Hilmer, S.N.; Reeve, E.; Potter, K.; Le Couteur, D.; Rigby, D.; Gnjidic, D.; Del Mar, C.B.; Roughead, E.E.; Page, A.; Jansen, J.; Martin, J.H. Reducing inappropriate polypharmacy: the process of deprescribing. JAMA Int. Med. 2015, 175, 827–834.
[33]	Masnoon, N.; Shakib, S.; Kalisch-Ellett, L.M.; Caughey, G. What is polypharmacy? A systematic review of definitions. BMC. Geriatr. 2017, 17, 230.
[34]	Ravn-Nielsen, L.V.; Duckert, M.L.; Lund, M.L.; Henriksen, J.P.; Nielsen, M.L.; Eriksen, C.S.; Buck, T.C.; Pottegård, A.; Hansen, M.R.; Hallas, J. Effect of an In-hospital multifaceted clinical pharmacist intervention on the risk of readmission: a randomized clinical trial. JAMA Int. Med. 2018, 178, 375–382.