摘要：
杨振军团队近年来发展了核苷(酸)脂材/肽类阳离子脂材, 包载各类功能寡核苷酸, 实现了siRNA、ASO、核酸适配体和mRNA及环二核苷酸的体外高效细胞转染及体内递送(Biomaterials, 2018, 2019; Mol Ther Nucleic Acid, 2021, 2023; RSC Med Chem, 2024; J Control Release, 2021; Thranostics, 2022; Eur J Med Chem, 2023), 特别是实现了肝以外胰腺癌组织的靶向递送(Biomed Pharmacother, 2024)。该类制剂的制备简单方便, 不依赖微流控技术, 体内未见毒副作用。
Supporting:
北京大学药学院天然药物及仿生药物全国重点实验室. 杨振军团队在胞苷脂材/肽类阳离子脂材/cGAMP衍生物制剂作为有效原位自体肿瘤疫苗方面取得新进展[J]. 中国药学(英文版), 2024, 33(5): 478-480.
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center. The research group of Prof. Zhenjun Yang has made new progress in cytidine/peptide cationic lipid/cGAMP derivative preparations as effective in situ autologous tumor vaccines[J]. Journal of Chinese Pharmaceutical Sciences, 2024, 33(5): 478-480.
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