孙崎团队在新类型alpha 7 nAChR正向变构调节剂及其改善认知障碍功能方面获得新进展

中国药学(英文版) ›› 2024, Vol. 33 ›› Issue (3): 272-274.

孙崎团队在新类型alpha 7 nAChR正向变构调节剂及其改善认知障碍功能方面获得新进展

北京大学药学院天然药物及仿生药物全国重点实验室

北京大学药学院天然药物及仿生药物全国重点实验室

收稿日期:2024-03-08 修回日期:2024-03-08 接受日期:2024-03-08 出版日期:2024-03-31 发布日期:2024-04-04

The research group of Prof. Qi Sun has made new progress in the development of allosteric activation of α7 nicotinic acetylcholine receptors for the improvement of cognitive deficits

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Cente

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Cente

Received:2024-03-08 Revised:2024-03-08 Accepted:2024-03-08 Online:2024-03-31 Published:2024-04-04

摘要/Abstract

关键词:

"> 2024年2月23日, 北京大学药学院天然药物及仿生药物全国重点实验室孙崎教授团队与青岛大学王克威教授团队合作在Journal of Medicinal Chemistry上在线发表了题为“Allosteric activation of α7 nicotinic acetylcholine receptors by novel 2-arylamino-thiazole-5-carboxylic acid amide derivatives for the improvement of cognitive deficits in mice”(新型2-芳氨基噻唑-5-酰胺类化合物变构增强α7尼古丁乙酰胆碱受体用于改善小鼠体内认知障碍)的研究工作。

Abstract:

The research group of Prof. Qi Sun has made new progress in the development of allosteric activation of α7 nicotinic acetylcholine receptors for the improvement of cognitive deficits.

Supporting:

北京大学药学院天然药物及仿生药物全国重点实验室. 孙崎团队在新类型alpha 7 nAChR正向变构调节剂及其改善认知障碍功能方面获得新进展[J]. 中国药学(英文版), 2024, 33(3): 272-274.

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Cente. The research group of Prof. Qi Sun has made new progress in the development of allosteric activation of α7 nicotinic acetylcholine receptors for the improvement of cognitive deficits[J]. Journal of Chinese Pharmaceutical Sciences, 2024, 33(3): 272-274.