马明团队在呋喃糖生物合成酶结构和催化机制方面取得新进展

中国药学(英文版) ›› 2023, Vol. 32 ›› Issue (2): 153-155.

马明团队在呋喃糖生物合成酶结构和催化机制方面取得新进展

北京大学药学院天然药物及仿生药物国家重点实验室

北京大学药学院天然药物及仿生药物国家重点实验室

收稿日期:2023-02-15 修回日期:2023-02-16 接受日期:2023-02-16 出版日期:2023-02-28 发布日期:2023-03-01

The team of Prof. Ming Ma has made new progress in the structure and catalytic mechanism of furanose biosynthetase

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center

Received:2023-02-15 Revised:2023-02-16 Accepted:2023-02-16 Online:2023-02-28 Published:2023-03-01

摘要/Abstract

摘要：

2023年1月12日, 北京大学药学院天然药物及仿生药物国家重点实验室马明研究团队在ACS Catalysis上发表了题为 “Structural Insight into a Metal-Dependent Mutase Revealing an Arginine Residue-Covalently Mediated Interconversion between Nucleotide-Based Pyranose and Furanose”的研究论文。该研究阐明了呋喃糖环生物合成中第一个离子依赖型变位酶(mutase)的晶体结构, 并揭示了一种精氨酸共价结合底物介导的吡喃糖环和呋喃糖环的相互转化机制。

Supporting:

北京大学药学院天然药物及仿生药物国家重点实验室. 马明团队在呋喃糖生物合成酶结构和催化机制方面取得新进展[J]. 中国药学(英文版), 2023, 32(2): 153-155.

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center. The team of Prof. Ming Ma has made new progress in the structure and catalytic mechanism of furanose biosynthetase[J]. Journal of Chinese Pharmaceutical Sciences, 2023, 32(2): 153-155.