环肽分子生物合成-马明团队发现第一个催化异构化/环化双功能硫酯酶并解析其晶体结构

中国药学(英文版) ›› 2021, Vol. 30 ›› Issue (9): 778-779.

环肽分子生物合成-马明团队发现第一个催化异构化/环化双功能硫酯酶并解析其晶体结构

北京大学药学院天然药物及仿生药物国家重点实验室

北京大学药学院天然药物及仿生药物国家重点实验室

收稿日期:2021-09-15 修回日期:2021-09-15 接受日期:2021-09-15 出版日期:2021-09-27 发布日期:2021-09-30

Cyclic peptide molecular biosynthesis-the group of Professor Ming Ma discovered the first catalytic isomerization/cyclic bifunctional thioesterase and analyzed its crystal structure

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center

Received:2021-09-15 Revised:2021-09-15 Accepted:2021-09-15 Online:2021-09-27 Published:2021-09-30

摘要/Abstract

摘要：

2021年9月7日, 北京大学药学院天然药物及仿生药物国家重点实验室马明研究团队在美国化学会《ACS Catalysis》上发表了题为“Functional characterization and crystal structure of the bifunctional thioesterase catalyzing epimerization and cyclization in skyllamycin biosynthesis”的研究论文。该研究发现了环肽分子生物合成中第一个催化异构化和环化的双功能硫酯酶, 解析其晶体结构并阐明了其活性位点关键残基。

Supporting:

北京大学药学院天然药物及仿生药物国家重点实验室. 环肽分子生物合成-马明团队发现第一个催化异构化/环化双功能硫酯酶并解析其晶体结构[J]. 中国药学(英文版), 2021, 30(9): 778-779.

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center. Cyclic peptide molecular biosynthesis-the group of Professor Ming Ma discovered the first catalytic isomerization/cyclic bifunctional thioesterase and analyzed its crystal structure[J]. Journal of Chinese Pharmaceutical Sciences, 2021, 30(9): 778-779.