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中国药学(英文版) ›› 2014, Vol. 23 ›› Issue (4): 251-255.DOI: 10.5246/jcps.2014.04.035

• 【研究论文】 • 上一篇    下一篇

消癌平化学成分研究

王艺润, 赵明波, 唐丽, 屠鹏飞*   

  1. 1. 中央民族大学 生命与环境科学学院, 北京 100081
    2. 北京大学医学部 药学院 天然药物及仿生药物国家重点实验室, 北京 100191 
  • 收稿日期:2014-01-13 修回日期:2014-02-11 出版日期:2014-04-28 发布日期:2014-02-20
  • 通讯作者: *Corresponding author. Tel.: 86-10-82802750; E-mail: pengfeitu@bjmu.edu.cn
  • 作者简介:*Corresponding author. Tel.: 86-10-82802750; E-mail: pengfeitu@bjmu.edu.cn

Chemical constituents from Xiaoaiping injection

Yirun Wang, Mingbo Zhao, Li Tang, Pengfei Tu*   

  1. 1. College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, China
    2. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China
  • Received:2014-01-13 Revised:2014-02-11 Online:2014-04-28 Published:2014-02-20
  • Contact: *Corresponding author. Tel.: 86-10-82802750; E-mail: pengfeitu@bjmu.edu.cn
  • About author:*Corresponding author. Tel.: 86-10-82802750; E-mail: pengfeitu@bjmu.edu.cn

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摘要：

消癌平注射液是通关藤提取物的单方制剂。本研究运用溶剂法结合硅胶、Sephadex LH-20、ODS和半制备高效液相色谱等色谱分离方法, 从消癌平注射液中间体的氯仿提取物中分离得到11个化合物, 通过综合分析MS、1D NMR和2D NMR等光谱数据, 11个化合物的结构分别鉴定为: 3-O-β-D-oleandropyranosyl-17β-tenacigenin B (1), tenacigenin B (2), 17β-tenacigenin B (3), marsdenoside F (4), tenacissoside G (5), tenacissoside I (6), tenacissoside H (7), marsdenoside D (8), tenacigenin A (9), marsdenoside I (10) 和tenacigenin C (11), 其中化合物1为新化合物。

关键词: 消癌平注射液, 通关藤, C21甾体类

Abstract:

Xiaoaiping injection is a single-prescription of Marsdenia tenacissima. One newcompound, tenacigenoside L(1), along with ten known compounds were isolated from the CHCl3-soluble fraction of Xiaoaiping injection extractby silica gel, ODS, Sephadex LH-20 and semi-preparative HPLC chromatography. The new compound was characterized as 3-O-β-D-oleandropyranosyl-17β-tenacigenin B. The ten known compounds were identified as tenacigenin B (2), 17β-tenacigenin B (3), marsdenoside F (4), tenacissoside G (5),tenacissoside I(6), tenacissoside H (7), marsdenoside D(8), tenacigenin A (9), marsdenoside I (10), and tenacigenin C (11). The structures of 11 compounds were elucidated on the basis of extensive analyses of spectroscopic data including MS, 1D NMR and 2D NMR, and comparison of their spectroscopic data with those reported in the literatures.

Key words: Xiaoaiping injection, Marsdenia tenacissima, Polyoxypregnane glycoside

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