传统中药白花蛇舌草的抗肿瘤活性研究

doi:10.5246/jcps.2013.03.039

传统中药白花蛇舌草的抗肿瘤活性研究

王英锋^*, 郑宜, 库宝善, 姚海燕, 姚广印, 万阳丽

1. 首都师范大学化学系, 北京 100048
2. 北京大学医学部基础医学院药理学系, 北京 100191
3. 鼎国生物科技有限公司, 北京 100083

收稿日期:2012-11-22 修回日期:2013-02-26 出版日期:2013-05-08 发布日期:2013-05-08
通讯作者: 王英锋*

Anti-tumor activity of Hedyotis diffusa Willd. in mice

Yingfeng Wang^*, Yi Zheng, Baoshan Ku, Haiyan Yao, Guangyin Yao, Yangli Wan

1. Department of Chemistry, Capital Normal University, Beijing 100048, China
2. Department of Pharmacology, Peking University Health Science Center, Beijing 100191, China
3. Dingguo Biological Technology Co., Ltd, Beijing 100083, China

Received:2012-11-22 Revised:2013-02-26 Online:2013-05-08 Published:2013-05-08
Contact: Yingfeng Wang*

摘要/Abstract

摘要：

研究了传统中药白花蛇舌草的乙醇提取有效部位对S180小鼠模型的肿瘤生长抑制作用、免疫系统及小鼠生存天数的影响。该醇提部位能有效抑制S180小鼠的肿瘤生长, 并延长荷瘤小鼠的生存天数。通过灌胃给药, 醇提有效部位在10 mg/kg的剂量下与阳性对照药物环磷酰胺 (20 mg/kg) 相比, 能够有效降低荷瘤小鼠体内的肿瘤大小与重量。对荷瘤小鼠的脾指数, 胸腺指数及血常规参数研究表明, 该醇提有效部位对荷瘤小鼠未见明显的毒副作用。总之, 研究结果表明白花蛇舌草的醇提部位具有有效的抗肿瘤活性。

关键词: 白花蛇舌草, 抗肿瘤, 免疫调节, 环烯醚萜苷, E-6-O-p-鸡屎藤苷甲酯

Abstract:

The whole plant with root of Hedyotis diffusa Willd. (AE) has been demonstrated to have anti-inflammatory, antioxidant, and anti-bacterial activities. In our study, we aim to examine the anti-tumor effect of alcoholic extract of AE in mice implanted with sarcoma S180 cells (SBT mice). We also compared the immune system function and the life span of SBT mice with that of control mice. We found that AE displayed a significant inhibitory effect on solid tumor growth, as well as increased the life span. At the dose of 10 mg/kg body weight, both tumor weight and volume were decreased significantly. We also measured several immune function markers, inlcuding spleen index (SI), thymus index (TI) and parameters of hematological. We observed no reduce in these markers, indicating that AE could inhibit tumor growth without affecting immune function in SBT mice.

Key words: Hedyotis diffusa Willd., Anti-tumor, Immunomodulatory, Iridoid, E-6-O-p-coumaroyl scandoside methyl ester

中图分类号:

R285.5

Supporting:

^*Corresponding author. Tel.: 86-10-68902687

王英锋^*, 郑宜, 库宝善, 姚海燕, 姚广印, 万阳丽. 传统中药白花蛇舌草的抗肿瘤活性研究[J]. , DOI: 10.5246/jcps.2013.03.039.

Yingfeng Wang^*, Yi Zheng, Baoshan Ku, Haiyan Yao, Guangyin Yao, Yangli Wan. Anti-tumor activity of Hedyotis diffusa Willd. in mice[J]. , DOI: 10.5246/jcps.2013.03.039.

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