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萘普生插层镁铝水滑石的合成及其结构表征

杜宝中*, 王汝敏   

  1. 1. 西北工业大学 理学院, 陕西 西安 710072
    2. 西安理工大学 应用化学系, 陕西 西安 710054
  • 收稿日期:2009-11-15 修回日期:2010-07-10 出版日期:2010-09-20 发布日期:2010-09-20
  • 通讯作者: 杜宝中*

Synthesis and characterizations of naproxen intercalated Mg-Al layered
double hydroxides

Bao-Zhong Du*, Ru-Min Wang   

  1. 1. Department of Applied Chemistry, Northwestern Polytechnical University, Xi'an 710072, China
    2. Department of Applied Chemistry, Xi’an University of Technology, Xi'an 710054, China
  • Received:2009-11-15 Revised:2010-07-10 Online:2010-09-20 Published:2010-09-20
  • Contact: Bao-Zhong Du*

摘要: 以镁铝水滑石为主体, 以抗炎药萘普生为客体, 采用分置镁、铝源、由共沉淀法和离子交换法合成得到超分子复合结构材料-萘普生插层镁铝水滑石。用XRD, FT-IR, TG-DTA对合成产物进行了表征。结果表明: 客体萘普生阴离子是以短轴单层垂直的方向插于层间; TG-DTA结果表明, 萘普生与主体之间通过氢键和静电场效应相互作用, 从而使其热稳定性明显提高。同时, 考查了萘普生插层的柱状水滑石分别在蒸馏水、生理盐水、模拟胃液 (pH 4.60) 及模拟肠液 (pH 7.43) 中的缓释性能, 结果表明: 萘普生在不同pH的溶液中, 缓释机理不同; 在pH 7.43模拟肠液中, 具有较强的缓释性能, 而在pH 4.60模拟胃液中释放度最大, 但缓释性能稍差; 同时, 共沉淀法比离子交换法制得萘普生插层镁铝水滑石具有良好的缓释性能, 且萘普生含量高释放平衡浓度大。该研究表明药物-无机混合物材料能够用作有效的药物传输系统。

关键词: 水滑石, 萘普生, 插层, 药物传输系统

Abstract: Naproxen (Nap), a non-steroidal anti-inflammatory drug (NSAIDs), was intercalated into the gallery of Mg-Al layered double hydroxides (LDHs) by ion exchange and co-precipitation with different location of magnesium ion and aluminum ion solutions, respectively. The product was characterized with powder X-ray diffraction (XRD), Fourier Transform Infrared spectral (FT-IR) and Thermogravimetry (TG). The results showed an expanded LDH structure, indicating that the drug was successfully intercalated into LDH with the monolayer perpendicular to (along the short axis orientation in proper angle) Nap anion. As compared to the pure form of Nap, the thermal stability of the intercalated Nap was significantly enhanced due to the host-guest interaction involving hydrogen bond and electrostatic attraction. We further investigated the drug release characteristics of the pillared LDH materials by a dissolution test in simulation gastrointestinal and intestinal fluids under different pH values. The results indicated that the release percentages decrease upon increasing pH from 4.60 to 7.43, likely due to the dependence of release mechanism on pH. We have carried out a kinetic simulation to the release data and found that the dissolution mechanism was mainly responsible for the release behavior of Nap-LDHs at pH 4.60, while the ion-exchange mechanism was responsible for that at pH 7.43. In addition, the initial release rates and equilibrium percent releases of the nanohybrids depended significantly on the synthesis methods, from which we have proposed a schematic model. The current study clearly showed that this drug-inorganic layered material has prospective applications in drug delivery system.

Key words: LDH, Naproxen, Intercalation, Drug delivery system

中图分类号: 

Supporting:

Foundation item: Science and Technique Foundation of Xi’an City (Grant No. YF07058).
*Corresponding author. Tel.: 86-29-82066325;