新型活性炭微球的制备及其对内源性分子的体外吸附性能研究

doi:10.5246/jcps.2011.03.038

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新型活性炭微球的制备及其对内源性分子的体外吸附性能研究

谢毅妮, 高峰^*, 袁慧慧, 梁晓怿, 凌立成

1. 上海市功能性材料化学重点实验室, 上海 200237
2. 华东理工大学药学院, 上海 200237
3. 华东理工大学化工学院, 上海 200237

收稿日期:2010-12-14 修回日期:2011-03-10 出版日期:2011-05-06 发布日期:2011-05-06
通讯作者: 高峰*

Preparation of a novel activated carbon microsphere and its in vitro adsorption characteristics for biological molecules

Yi-Ni Xie, Feng Gao^*, Hui-Hui Yuan, Xiao-Yi Liang, Li-Cheng Ling

1. Shanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, Shanghai 200237, China
2. School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
3. School of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, China

Received:2010-12-14 Revised:2011-03-10 Online:2011-05-06 Published:2011-05-06
Contact: Feng Gao*

摘要/Abstract

摘要：

制备一类新型的沥青基活性炭微球并考察其对内源性分子的吸附性能。采用乳化法制得沥青原球, 经氧化、炭化和水蒸气活化, 制得孔径不同的活性炭微球。通过体外吸附实验筛选, 得到BET比表面积为1566 m²/g, 孔容量为 0.653 cm³/g, 微孔容量为 0.478 cm³/g的活性炭微球, 对葡萄糖或肌酐的吸附率高; 与药用活性炭粉末相比, 其对消化酶类分子的吸附率显著降低。总之, 制得的比表面积大、微孔隙结构发达的活性炭微球, 具有良好的选择性吸附内源性分子的特性, 可能作为候选药物, 用于选择性吸附经肠道吸收的内源性分子。

关键词: 活性炭微球, 孔隙结构, 吸附特性, 内源性小分子, 消化酶

Abstract:

We prepared a novel pitch-based activated carbon microsphere (ACM) and studied its in vitro adsorption characteristics for biological molecules. The original spherical asphalt particles were prepared through bitumen emulsification. After oxidation and burning, ACMs with a range of parameters were prepared. In vitro adsorption experiments of ACMs for biological molecules were carried out. The prepared ACMs possessed a BET specific surface of 1566 m²/g with a voidage of 0.653 cm³/gand a volume of micropores of 0.478 cm³/g. They showed high adsorption for glucose and creatintine. Compared with the medically used carbon powder, the prepared ACMs exhibited significantly lower adsorption for digestion enzymes. In conclusion, the prepared ACMs, as an oral adsorbent candidate, possessed higher BET specific surface area and larger volume of micropores; they also exhibited favorable selective adsorption features for biological molecules.

Key words: Activated carbon microsphere, Porous structure, Adsorption characteristics, Biological molecules, Digestion enzymes

中图分类号:

R943

Supporting:

Foundation item: 111 Program of China (Grant No. B07023).
^*Corresponding author. Tel.: 86-21-64252449

谢毅妮, 高峰^*, 袁慧慧, 梁晓怿, 凌立成. 新型活性炭微球的制备及其对内源性分子的体外吸附性能研究[J]. , DOI: 10.5246/jcps.2011.03.038.

Yi-Ni Xie, Feng Gao^*, Hui-Hui Yuan, Xiao-Yi Liang, Li-Cheng Ling.

Preparation of a novel activated carbon microsphere and its in vitro adsorption characteristics for biological molecules

[J]. , DOI: 10.5246/jcps.2011.03.038.

新型活性炭微球的制备及其对内源性分子的体外吸附性能研究

Preparation of a novel activated carbon microsphere and its in vitro adsorption characteristics for biological molecules

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