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高锰酸钾-甲醛流动注射化学发光体系测定美洛昔康胶囊的含量

贾宝秀*, 曹明亮, 刘彩红, 李玉琴, 李珂, 齐永秀   

  1. 泰山医学院药学院, 山东 泰安 271016
  • 收稿日期:2007-11-08 修回日期:2008-01-10 出版日期:2008-03-15 发布日期:2008-03-15
  • 通讯作者: 贾宝秀*

Flow injection chemiluminescence determination of meloxicam using potassium permanganate and formaldehyde system

Bao-Xiu Jia*, Ming-Liang Cao, Cai-Hong Liu, Yu-Qin Li, Ke Li, Yong-Xiu Qi   

  1. College of Pharmaceutical, Taishan Medical University, Tai'an 271016, China
  • Received:2007-11-08 Revised:2008-01-10 Online:2008-03-15 Published:2008-03-15
  • Contact: Bao-Xiu Jia*

摘要:

在盐酸酸性条件下, 美洛昔康与高锰酸钾发生化学发光反应, 甲醛对此发光体系有强烈的增敏作用。在此基础上, 建立了一种快速、准确的测定美洛昔康胶囊含量的流动注射化学发光法。在最佳实验条件下, 测得的线性范围为1.020.0 μg/mL, 检测限为25.6 ng/mL, 相对标准偏差为2.1%。常见药物赋形剂对本法没有干扰, 方法用于美洛昔康胶囊含量的测定,结果令人满意。

关键词: 美洛昔康, 美洛昔康, 美洛昔康, 流动注射化学发光, 流动注射化学发光, 流动注射化学发光, 甲醛, 甲醛, 甲醛, 药物分析, 药物分析, 药物分析

Abstract: A simple, rapid and sensitive flow injection chemiluminescence (FI-CL) method has been developed for the determination of meloxicam. The method is based on the CL-emitting reaction between meloxicam and potassium permanganate in a hydrochloric acid medium, enhanced by formaldehyde (HCHO). Under optimum conditions, calibration curve over the range of 1.0–20.0 μg/mL was obtained. The proposed method was successfully applied to the determination of meloxicam in capsules with no evidence of interference from common excipients. The detection limit of this method was 25.6 ng/mL. The relative standard deviation was 2.1% for 10.0 μg/mL meloxicam. The sample throughput was found to be 120 samples/h.

Key words: Meloxicam, Meloxicam, Flow injection chemiluminescence, Flow injection chemiluminescence, Formaldehyde, Formaldehyde, Pharmaceutical analysis, Pharmaceutical analysis

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Supporting: *Corresponding author. Tel.: 86-538-6235712