石南藤化学成分研究

石南藤化学成分研究

赵云, 阮金兰^*

华中科技大学同济药学院, 湖北武汉 430030

收稿日期:2005-08-21 修回日期:2006-02-10 出版日期:2006-03-15 发布日期:2006-03-15
通讯作者: 阮金兰*

Chemical Constituents from Piper wallichii

ZHAO Yun, RUAN Jin-lan^*

College of Pharmacy, Tongji Medical Center, Huazhong University of Science and Technology, Wuhan 430030, China

Received:2005-08-21 Revised:2006-02-10 Online:2006-03-15 Published:2006-03-15
Contact: RUAN Jin-lan*

摘要/Abstract

摘要： 目的对石南藤Piper wallichii化学成分进行研究。方法应用硅胶、葡聚糖凝胶等色谱技术分离纯化, 应用波谱技术确定化合物的结构。结果从石南藤中分离得到了5个化合物, 分别为 piperlonguminine (trans, trans) (1), 4-羟基-3,5-二甲氧基-苯甲酸(2), galgravin(3), β-谷甾醇(4) 以及胡萝卜苷(5)。结论五个化合物均为首次从石南藤中得到, 化合物1～3为首次从胡椒属中得到。

关键词: 石南藤, 石南藤, 石南藤, 胡椒碱, 胡椒碱, 胡椒碱, 4-羟基-3,5-二甲氧基-苯甲酸, 4-羟基-3,5-二甲氧基-苯甲酸, 4-羟基-3,5-二甲氧基-苯甲酸, galgravin, galgravin, galgravin

Abstract: Aim To investigate the chemical constituents of Piper wallichii. Methods Five compounds were isolated by silica gel column chromatography and Sephadex LH-20 gel column chromatography, and the structures of compounds were identified by spectral analysis. Result Five compounds were identified as piperlonguminine (trans, trans) (1), 4-hydroxy-3,5-dimethoxy-benzoic acid (2), galgravin (3), β-sitosterol (4), and daucosterol (5). Conclusion Five compounds were isolated from Piper wallichii for the first time, and compounds 1-3 were isolated from this genus for the first time.

Key words: Piper wallichii, Piper wallichii, piperlonguminine, piperlonguminine, 4-hydroxy-3,5-dimethoxy-benzoic acid, 4-hydroxy-3,5-dimethoxy-benzoic acid, galgravin, galgravin

中图分类号:

R284.1

R284.2

Supporting: ^*Corresponding author. Tel.: 86-27-83692892

赵云, 阮金兰^*. 石南藤化学成分研究[J]. .

ZHAO Yun, RUAN Jin-lan^*. Chemical Constituents from Piper wallichii[J]. .

[1]	周毅, 王婷, 赵佳佳, 王凌, 蒋学华. 胡椒碱和(R)-(+)-香茅醛对多药耐药乳腺癌细胞的耐药逆转作用[J]. 中国药学(英文版), 2016, 25(5): 351-356.
[2]	梁云爱. 二阶导数差示脉冲极谱法用于中草药有效成分的定量研究[J]. , 1997, 6(3): 154-159.