关键词: 奥拉西坦, 奥拉西坦, 奥拉西坦, 高效液相色谱法, 高效液相色谱法, 高效液相色谱法, 药代动力学, 药代动力学, 药代动力学

Abstract: Aim To study the pharmacokinetics of oxiracetam after single and multiple intravenous administrations in healthy volunteers. Method A HPLC method was used to determine the serum concentration of oxiracetam after intravenous single dose and daily dose of 2 000 mg for 7 d in ten Chinese healthy volunteers. Pharmacokinetic analysis was carried out using Drug And Statistic software. Results The AUC0~12, AUC0~∞, Ke, t1/2, MRT after a single dose of 2 000 mg oxiracetam were 256.26±16.84 μg·mL^-1·h^-1, 276.74±18.11 μg·mL^-1·h^-1, 0.18±0.03 h^-1, 3.84±0.64 h, and 4.39±0.39 h, and after multiple doses of oxiracetam were 259.36±25.43 μg·mL^-1·h^-1, 285.59±27.38 μg·mL^-1·h^-1, 0.17±0.04 h^-1, 4.14±0.82 h, and 4.87±0.69 h, respectively. Conclusion The pharmacokinetic parameters of oxiracetam do not differ remarkably after single and multiple intravenous administration and there is accumulation in serum after 2000 mg multiple intravenous administration once a day for 7 d.

Key words: oxiracetam, oxiracetam, high performance liquid chromatography, high performance liquid chromatography, pharmacokinetic, pharmacokinetic