C4,C7位修饰的新的四环素类衍生物的合成和神经保护活性

• 简报 • 上一篇

C4,C7位修饰的新的四环素类衍生物的合成和神经保护活性

周站云, 王洪涛, 王孝伟, 王瑞平, DuYansheng, 刘俊义^*

收稿日期:2004-03-15 修回日期:2004-08-10 出版日期:2004-09-15 发布日期:2004-09-15
通讯作者: 刘俊义*

Synthesis and Neuroprotective Activity of Novel C4, C7 Derivatives in Tetracycline Series

ZHOU Zhan-yun, WANG Hong-tao, WANG Xiao-wei, WANG Rui-ping, DU Yan-sheng, LIU Jun-yi^*

Received:2004-03-15 Revised:2004-08-10 Online:2004-09-15 Published:2004-09-15
Contact: LIU Jun-yi*

摘要/Abstract

关键词: 去二甲胺基四环素类似物, 去二甲胺基四环素类似物, 去二甲胺基四环素类似物, 米诺环素碘化物, 米诺环素碘化物, 米诺环素碘化物, 神经保护作用, 神经保护作用, 神经保护作用, 还原, 还原, 还原

Key words: dedimethylaminotetracycline analogs, dedimethylaminotetracycline analogs, minocycline iodide, minocycline iodide, neuroprotective effects, neuroprotective effects, reduction, reduction

中图分类号:

R916.41

R964

Supporting: Foundation item: National Natural Science Foundation of China (20372005).
^*Corresponding author. Tel.: 86-10-82801504; fax: 86-10-62015584

周站云, 王洪涛, 王孝伟, 王瑞平, DuYansheng, 刘俊义^*. C4,C7位修饰的新的四环素类衍生物的合成和神经保护活性[J]. .

ZHOU Zhan-yun, WANG Hong-tao, WANG Xiao-wei, WANG Rui-ping, DU Yan-sheng, LIU Jun-yi^*. Synthesis and Neuroprotective Activity of Novel C4, C7 Derivatives in Tetracycline Series[J]. .

[1] Boothe JH, Morton J, Petisi JP, et al. Tetracycline [J]. J Am Chem Soc, 1953, 75: 4621.
[2] Dürckheimer W, Tetracycline: Chemistry, Biochemistry and Structure-activity Relation [M]. 14th Ed. New York: Angnew Chem Int., 1975, 721-774.
[3] Gabler WL, Smith J, Tsukuda N, et al. Comparison of doxycycline and a chemically modified inhibition of leukocyte function [J]. Res Commun Chem Pathol Pharmacol, 1992, 78: 151-160.
[4] Golub LM, Ramamurthyl NS, Liavaneras A, et al. A chemically modified nonantimicrobial tetracycline (CMT-8) inhibits gingival matrix metalloproteinases, periodontal breakdown, and extra-oral bone loss in ovariectomized rats [J]. Ann NY Acad Sci, 1999, 878: 290-310.
[5] Golub LM, Lee HM, Ryan ME, et al. Tetracyclines inhibit connective tissue breakdown by multiple non-antimicrobial mechanisms [J]. Adv Den Res, 1998, 12: 12-26.
[6] Tikka TM, Koistinaho J E. Minocycline provides neuroprotection against n-methyl-D-aspartate neurotoxicity by inhibition of microglia [J]. J Immunol, 2001, 166: 7527-7533.
[7] Tikka T, Fiebich BL, Goldsteins G, et al. Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia [J]. J Neurosci, 2001, 21: 2580-2588.
[8] Trjänheikki J, Tikka T, Keinänen R, et al. A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window [J]. Proc Natl Acad Sci USA, 1999, 96: 13496-13500.
[9] Trjänheikki J, Keinänen R, Pellilla M, et al. Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia [ J]. Proc Natl Acad Sci USA, 1998, 95: 15769-15774.
[10] Rogalski W, Hlavka JJ, Boothe JH. The Tetracyclines in Handbook of Experimental Pharmacology [M]. 3nd Ed. Berlin: Springer-Verlag, 1985. 179-226.
[11] Du Y, Bales KR, Dodel RC, et al. Activation of a caspase 3-related cysteine protease is required for glutamate-mediated apoptosis of cultured cerebellar granule neurons [ J]. Proc Natl Acad Sci USA, 1997, 94: 11657-11662.
[12] Du Y, Ma Z, Lin S, et al. Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of parkinson’s disease [J]. Proc Natl Acad Sci USA, 2001, 98: 14669-14674.

[1]	陆益奔, 张苗, 郑永军, 侯昕宇, 贺牧野, 楼开炎, 高峰. 基于mPEG-β-环糊精和喜树碱前药的还原敏感自组装胶束作为药物释放载体[J]. 中国药学(英文版), 2021, 30(12): 941-955.
[2]	黄晋, 杨玲馨, 杨宁, 袁博文, 张浩, 王梦月. 荨麻抑制前列腺增生药理作用研究[J]. 中国药学(英文版), 2020, 29(4): 236-243.
[3]	闫仪, 崔仕贺, 孙晶, 李飘飘, 张海涛, 王坚成. 具有还原敏感可断裂的疏水尾链的新型阳离子脂质用于siRNA递送的研究[J]. 中国药学(英文版), 2018, 27(6): 383-396.
[4]	国伟杰, 李国梁, 侯玉雪, 王蓉蓉, 刘洋, 刘小红, 高华, 王威. 红藻鸭毛藻化学成分研究[J]. 中国药学(英文版), 2017, 26(10): 754-762.
[5]	金天云, 沈涛, 周明星, 李爱玲, 封达, 郑博伦, 巩洁, 孙佳伟, 李玲玉, 向兰. 马齿苋的化学成分及其生物活性研究[J]. 中国药学(英文版), 2016, 25(12): 898-905.
[6]	沈笑飞, 曾少华, 吴敏, 刘春朝, 王瑛. 黑果枸杞原花青素合成相关无色花色素还原酶基因和花青素还原酶基因的克隆及表达分析[J]. 中国药学(英文版), 2014, 23(6): 369-377.
[7]	付嫣然, 杨农, 李月琴, 赵友云, 叶索夫, 刘丽慧, 曾慧慧. 硫氧还蛋白还原酶作为新型生物标志物在乳腺癌诊断和治疗中的价值[J]. 中国药学(英文版), 2014, 23(10): 711-715.
[8]	田超, 张志丽, 刘俊义^*. 8-去氮-5,6,7,8-四氢甲氨蝶呤类似物的合成及二氢叶酸合成酶抑制活性评估[J]. , 2012, 21(2): 142-148.
[9]	杨颖, 王超^*. 多巯基功能性保护氨基酸的合成[J]. , 2011, 20(2): 195-198.
[10]	傅佳凝, 王静瑜, 王立辉, 王磊, 唐菀晨, 蔡高雄, 刘密, 曾慧慧^*. 国家一类抗肿瘤新药有机硒化合物乙烷硒啉的药效药理作用[J]. , 2010, 19(3): 163-168.
[11]	蔡正艳^*, 潘竞, 郝群, 周伟澄, 张陆勇. 4-苯氧基喹啉羟甲戊二酸内酯类的合成及抑制HMG CoA还原酶活性研究[J]. , 2010, 19(1): 15-23.
[12]	王立辉, 曾慧慧^*. 创新抗肿瘤药物—乙烷硒啉对小鼠H22肝癌皮下移植瘤的氧化还原状态研究[J]. , 2009, 18(3): 245-251.
[13]	张奎平, 雷小平^*. 度他雄胺的合成工艺[J]. , 2007, 16(3): 233-235.
[14]	李仁利, 倪文升, 赵维璋. 5-取代-2,4-二氨基嘧啶对大肠杆菌二氢叶酸还原酶抑制作用的定量构效关系的研究[J]. , 1994, 3(1): 6-11.