盐酸美普他酚的毛细管电泳手性分离

盐酸美普他酚的毛细管电泳手性分离

郁韵秋, 陈燕, 李妮, 仇缀百^*

复旦大学药学院, 上海 200032

收稿日期:2004-03-16 修回日期:2004-08-10 出版日期:2004-09-15 发布日期:2004-09-15
通讯作者: 仇缀百*

Enantiomeric Separation of Meptazinol Hydrochloride by Capillary Electrophoresis

YU Yun-qiu, CHEN Yan, LI Ni, QIU Zhui-bai^*

School of Pharmacy, Fudan University, Shanghai 200032, China

Received:2004-03-16 Revised:2004-08-10 Online:2004-09-15 Published:2004-09-15
Contact: QIU Zhui-bai*

摘要/Abstract

摘要： 目的建立了一种盐酸美普他酚的毛细管电泳分离方法. 方法采用开管式熔融石英毛细管柱, 以β-环糊精为手性添加剂可使盐酸美普他酚对映体分离. 对β-环糊精类型进行了选择,对缓冲液pH、三甲基-β-环糊精的浓度、有机添加剂等实验条件进行了优化. 结果在所确定的条件下盐酸美普他酚对映体达到基线分离. 结论所建立的方法方便、快速, 可用于该类药物的手性研究.

关键词: 盐酸美普他酚, 盐酸美普他酚, 盐酸美普他酚, 高效毛细管电泳, 高效毛细管电泳, 高效毛细管电泳, 手性分离, 手性分离, 手性分离

Abstract: Aim To establish a capillary electrophoresis method for enantiomeric separation of meptazinol hydrochloride. Methods The separation conditions such as cyclodextrin (CD) type, buffer pH, concentration of 2,3,6-O-trimethyl-β-cyclodextrin and organic additives were optimized. An optimum concentration was 30 mmol·L^-1 phosphate (pH 7.02) with 10% (W/V) TM-β-CD and 2% acetonitrile. Results Baseline resolution of the enantiomer was readily achieved using 2, 3, 6-O-trimethyl-β-cyclodextrin. Conclusion This is a convenient method for fast enantiomeric resolution of meptazinol hydrochloride.

Key words: meptazinol hydrochloride, meptazinol hydrochloride, enantiomeric separation, enantiomeric separation, capillary electrophoresis, capillary electrophoresis

中图分类号:

R916.64

R917

Supporting: Foundation item: National Natural Science Foundation of China (30271539).
^*Corresponding author. Tel.: 86-21-54237595

郁韵秋, 陈燕, 李妮, 仇缀百^*. 盐酸美普他酚的毛细管电泳手性分离[J]. .

YU Yun-qiu, CHEN Yan, LI Ni, QIU Zhui-bai^*. Enantiomeric Separation of Meptazinol Hydrochloride by Capillary Electrophoresis[J]. .

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