(E)-4-芳酰氧基苯基丙烯酸类衍生物的合成及抑癌活性

(E)-4-芳酰氧基苯基丙烯酸类衍生物的合成及抑癌活性

刘鹰翔, 计志忠, 牟孝硕, 张宝凤

1.广东药学院药学系, 广州 510224;
2.沈阳药科大学制药系, 沈阳 110015

收稿日期:2002-03-12 修回日期:2002-07-05 出版日期:2002-09-15 发布日期:2002-09-15

Synthesis and Anticancer Activity of (E)-4-Acyloxypropenoic Acid Derivatives

Liu Yingxiang, Ji Zhizhong, Mu Xiaoshuo, Zhang Baofeng

1.Department of Pharmacy, Guangdong Pharmacy College,Guangzhou 510224;
2.Department of Pharmaceutical Engineering, Shenyang Pharmacy University, Shenyang 110015

Received:2002-03-12 Revised:2002-07-05 Online:2002-09-15 Published:2002-09-15

摘要/Abstract

摘要： 本文报道了18个(E)-4-芳酰氧基苯基丙烯酸类衍生物的设计与合成. 其中17个化合物未见文献报道. 所有目标物的化学结构经元素分析、红外光谱和核磁共振氢谱确证. 初步体外抑癌试验结果表明, 在0.3μmol·L^-1浓度下化合物3e、3f、3g、3h、3k、4h和4j对小鼠艾氏腹水癌(EAC)呈现显著抑制作用.

关键词: (E)芳酰氧基苯基丙烯酸, Doebner反应, 抑癌活性

Abstract: Eighteen compounds of (E)-3-substituted-4-acyloxyphenylpropenoic acid were designed and synthesized, of which seventeen final target compounds had never been reported. Their chemical structures were determined by elementary analyses and IR as well as ¹H NMR, etc. Preliminary results of anticancer tests in vitro showed that compounds 3e, 3f, 3g,3h,3k,4h and 4j had significant anticancer activities on Ehrlich ascites carcinoma cells at 0.3 mmol·L^-1 concentration.

Key words: (E)4-Aryloxyphenylpropenoic acid, (E)4-Aryloxyphenylpropenoic acid, Doebner reaction, Doebner reaction, Anticancer activity, Anticancer activity

Supporting:

刘鹰翔, 计志忠, 牟孝硕, 张宝凤. (E)-4-芳酰氧基苯基丙烯酸类衍生物的合成及抑癌活性[J]. .

Liu Yingxiang, Ji Zhizhong, Mu Xiaoshuo, Zhang Baofeng . Synthesis and Anticancer Activity of (E)-4-Acyloxypropenoic Acid Derivatives[J]. .