RGD多肽-氨基聚乙二醇-乳糖苷糖缀合物的合成

RGD多肽-氨基聚乙二醇-乳糖苷糖缀合物的合成

牛利民, 李庆, 苏斌, 李辉, 蔡孟深, 李中军^*

北京大学药学院化学生物系, 北京100083

收稿日期:2002-04-15 修回日期:2002-06-20 出版日期:2002-09-15 发布日期:2002-09-15
通讯作者: 李中军*

Synthesis of RGD-aPEG-Lactoside, A Potential Anti-metastasis Glycoconjugate

Niu Limin, Li Qing, Su Bin, Li Hui, Cai Mengshen, Li Zhongjun^*

Department of Chemical biology, School of Pharmaceutical Sciences, Peking University, Beijing 100083

Received:2002-04-15 Revised:2002-06-20 Online:2002-09-15 Published:2002-09-15
Contact: Li Zhongjun*

摘要/Abstract

摘要： 肿瘤细胞和宿主细胞或细胞外基质之间的相互粘连作用, 是发生肿瘤转移的重要环节之一。RGD多肽聚乙二醇杂合物和寡糖的聚乙二醇缀合物都具有抗肿瘤转移的作用, RGD多肽-聚乙二醇-寡糖的杂合物也应当具有此功能的潜力。为了探索该类化合物的作用,设计且成功地合成聚乙二醇-RGD多肽-寡糖缀合物。

关键词: RGD多肽, 寡糖, 聚乙二醇(PEG), 糖肽缀合物, 抗肿瘤转移

Abstract: The adhesive interaction between tumor cells and host cells or the extra cellular matrix plays a crucial role in metastasis. Due to the anti-metastasis effects of RGD (Arginyl-Glycyl-Aspartic acid) conjugated with PEG, hybrids of PEG armed RGD and oligosaccharides would have potential regulating effects during the metastasis process. In order to investigate this effect, GD-aPEG-Lactosid, RGD-aPEG-Lactoside glycopeptides armed by PEG were designed and successfully prepared by DCC-HOBt coupling method from aPEG-Lactoside, Boc-Gly-Asp(OBn)-OH.

Key words: RGD, RGD, Oligosaccharides, Oligosaccharides, PEG, PEG, Anti-metastasis, Anti-metastasis, Glycopeptides, Glycopeptides

Supporting:

牛利民, 李庆, 苏斌, 李辉, 蔡孟深, 李中军^*. RGD多肽-氨基聚乙二醇-乳糖苷糖缀合物的合成[J]. .

Niu Limin, Li Qing, Su Bin, Li Hui, Cai Mengshen, Li Zhongjun^*. Synthesis of RGD-aPEG-Lactoside, A Potential Anti-metastasis Glycoconjugate[J]. .

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