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200株弯曲菌对30种抗生素敏感性研究

侯凤琴, 沈宝铨, 孙新婷   

  1. 北京医科大学第一医院感染疾病科, 北京 100034
  • 收稿日期:2000-04-18 修回日期:2000-06-22 出版日期:2000-12-15 发布日期:2000-12-15

Susceptibility of 30 Antimicrobial Agents in 200 Strains of Campylobacters

Hou Fengqin, Shen Baoquan, Sun Xinting   

  1. Department of Infectious Diseases, The First Teaching Hospital, Beijing Medical University, Beijing 100034
  • Received:2000-04-18 Revised:2000-06-22 Online:2000-12-15 Published:2000-12-15

摘要: 为了解近几年弯曲菌对抗生素的敏感性, 我们采用琼脂扩散法进行了200株弯曲菌对30种抗生素的敏感实验, 结果19941998氨基糖甙类、硫霉素、多粘菌素B、克拉霉素、交沙霉素、麦迪霉素均无耐药菌。红霉素耐药率为3%; 氟喹诺酮类为44.5%。另外, 氟喹诺酮类有完全性交叉耐药。红霉素和庆大霉素耐药菌五年来相对稳定, 仍可用来治疗弯曲菌肠炎。我们这一地区氟喹诺酮类严重耐药, 将来应严格控制使用。

关键词: 弯曲菌, 耐药

Abstract: To access the variance of antibiotic-resistance, we investigated the susceptibility of 30 antimicrobial agents in Campylobacters isolated from 1994 to 1998 using the agar dilution method. All Campylobacter was susceptible to aminoglycoside, imipenem, polymycin B, clarithromycin, josamycin and medemycin. Of the 200 strains of Campylobacters, 3% were resistant to erythromycin; 44.5% to fluoroquinolones. Complete cross-resistance among the fluoroquinolones was observed. The rate of resistance to erythromycin and gentamycin remained relatively lower and stable over the past five years, so these two drugs remain to be the choice for the treatment of Campylobacter infections. The rate of drug resistance to fluoroquinolones of Campylobacters in Beijing area is so high that the application of these drugs should be modulated strictly.

Key words: Campylobacter, Campylobacter, Drug-Resistance, Drug-Resistance

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