C18二萜生物碱吉乌定的结构研究

C18二萜生物碱吉乌定的结构研究

冯锋, 叶文才, 刘静涵, 赵守训, Ian D. Williams, 车镇涛

1. 中国药科大学天然药物化学教研室,南京210009;
2. 香港理工大学化学系;
3. 香港中文大学中药学院

收稿日期:2000-01-17 修回日期:2000-05-23 出版日期:2000-12-15 发布日期:2000-12-15

Kiridine, A C18-Diterpene Alkaloid from Aconitum kirinense

Feng Feng, Ye Wencai, Liu Jinghan, Zhao Shouxun, Ian D. Williams, Che Chuntao

1. Department of Phytochemistry, China Pharmaceutical University, Nanjing 210009;
2. Department of Chemistry, Hong Kong University of Science and Technology, Hong Kong;
3. School of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong

Received:2000-01-17 Revised:2000-05-23 Online:2000-12-15 Published:2000-12-15

摘要/Abstract

摘要： 从吉林乌头(Aconitum kirinense)中分离得到一个C18二萜生物碱吉乌定,用MS,1D和2D NMR以及单晶X-射线分析等方法确定了它的结构为3β,4-epoxy-20-ethyl-9,14β-methylenedioxy-16β-methyl-1α,8-dihydroxyaconitane,该化合物为第一个含有9,14-亚甲二氧基和14β取代基的去甲二萜生物碱。

关键词: 吉林乌头, 毛茛科, 二萜生物碱, 吉乌定

Abstract: Kiridine, a new C18-diterpenoid alkaloid, was isolated from the roots of Aconitum kirinense. Its structure was elucidated by MS, 1D- and 2D- NMR, and mono-crystal X-ray analysis. It is the first norditerpene alkaloid containing a 9,14-methylenedioxy group and the substituent at C-14 is β-configuration.

Key words: Aconitum kirinense, Aconitum kirinense, Ranunculaceae, Ranunculaceae, Diterpene alkaloids, Diterpene alkaloids, Kiridine, Kiridine

Supporting:

冯锋, 叶文才, 刘静涵, 赵守训, Ian D. Williams, 车镇涛. C18二萜生物碱吉乌定的结构研究[J]. .

Feng Feng, Ye Wencai, Liu Jinghan, Zhao Shouxun, Ian D. Williams, Che Chuntao . Kiridine, A C18-Diterpene Alkaloid from Aconitum kirinense[J]. .