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高于饱和装填量时的平板混合药膜体系释放动力学模型

徐铜文, 何炳林   

  1. 1.中国科技大学应用化学系, 合肥 230026;
    2.南开大学吸附分离功能高分子材料国家重点实验室, 天津 300071
  • 收稿日期:1998-10-05 修回日期:1999-02-26 出版日期:1999-12-15 发布日期:1999-12-15

Modeling of Sustained Drug Release from a Planar Matrix with a Super-saturation Loading

Xu Tongwen, He Binglin   

  1. 1.Department of Applied Chemistry University of Science and Technology of China, Hefei 230026;
    2.The State key Lab of Functional Polymer Materials for Adsorption and Separation, Nankai University Tianjin 300071
  • Received:1998-10-05 Revised:1999-02-26 Online:1999-12-15 Published:1999-12-15

摘要:

针对最一般的情况建立了Cd>Cs时的混合药膜的释放动力学模型,用拉氏变换求得了解析解,该模型可通过相应简化而获得一些特定情况的解; 5-氟脲嘧啶/EVAL混合药膜体系的释放实验数据对所提出的模型进行了验证并与Higuchi模型进行了比较。结果表明:在中等装填量的情况下如:15.5d<123.6mg·cm-3,本文模型与实验数据符合的很好,预测精度比Higuchi模型高,特别是在Cd<15.5mg·cm-3; 这两个模型均不能较好描述较高装填量的情况,Cd>210mg.cm-3,这种情况我们在别处已经作过讨论(8,9)

关键词: 氟脲嘧啶, 乙烯乙烯醇共聚物(EVAL), 模型, 平板混合药膜, 控制释放, 扩散

Abstract:

This paper concerns with matrix-diffusion mechanism in slab monolithic matrixin the case that a drug loading is above its saturation level. A comprehensive model is proposed andthe general solutions are acquired by Laplace transform, from which a special case can be derived.The equations obtained are compared with Higuchi's model and tested with a 5-fluorouracil(5-Fu) loaded poly (ethylene-vinylalcohol), i. e., 5 -Fu/EVAL matrix system. The experimental data haveconfirmed the validity of the theoretical model at middle drug loadings, e.g., those between 15.5 and 123.6 mg.cm-3. The model proposed is superior to Higuchi's for a relatively low loading system, muchas that less than 15.5 mg.cm-3 and can theoretically support the hypotheses of Higuchi's model.Neither of these two theoretical models can describe the high drug loading systems, such as thoseloaded over 210 mg.cm-3. This case has been discussed elsewhere.

Key words: 5-Fluorouracil(5-Fu), Poly(ethylene-vinyl alcohol), Modeling, Planar matrix, Sustained drug

Supporting:

Supporrted by the Youth Foundation of US TC and the Foundation of the State Key Lab Of Func. Poly. for Adsorption and Separation