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鼓槌石中毛兰素及鼓槌素对B16/h MDR-1细胞的抗多药耐药性的作用

马国祥*, Gerlad A. LeBlanc   

  1. 1. 南京中医药大学 中医药研究院, 南京 210009;
    2. 美国北卡罗来纳州立大学 毒理系, 罗利 NC27695
  • 收稿日期:1997-03-08 修回日期:1998-03-26 出版日期:1998-09-15 发布日期:1998-09-15
  • 通讯作者: 马国祥*

The Activity of Erianin and Chrysotoxine from Dendrobium chrysotoxum to Reverse Multidrug Resistance in B16/h MDR-1 Cells

Guo-Xiang Ma*, Gerald A. LeBlanc   

  1. 1. Institute of Traditional Chinese Medicine and Pharmacology, Nanjing University of Traditional Chinese Medicine, Nanjing 210029;
    2. Department of Toxicology, North Carolina State University, Raleigh, NC 27695-7633, USA
  • Received:1997-03-08 Revised:1998-03-26 Online:1998-09-15 Published:1998-09-15
  • Contact: Guo-Xiang Ma*

摘要: 采用转染上人类MDR-1基因, 对长春花碱及阿霉素具有交叉耐药性的鼠黑色素瘤细胞株对从鼓槌石斛中分得的二个氢芪类化合物毛兰素及鼓槌素的抗肿瘤多药耐药性进行研究。结果表明: 二个化合物均能在一定程度上增加阿霉素在多药耐药细胞株中的积累, 有进一步研究的价值。

关键词: 二氢芪, 毛兰素, 鼓槌素, 多药耐药, P-糖蛋白

Abstract: The ability of two dihydrostilbene derivatives erianin and chrysotoxine from Dendrobium chrysotoxum to reverse multidrug resistant (MDR) cells was investigated using murine B16 melanoma cells transfected with the human MDR-1 gene and crossresistant to vinblastine and adriamycin (B16/h MDR-1 cells). Both of the two compounds were shown to increase the accumulation of adriamycin, the P-glycoprotein (P-gp) substrate, in B16/h MDR-1 transfectants.

Key words: Dihydrostilbene, Erianin, Chrysotoxine, Multidrug resistance (MDR), Pglycoprotein (P-gp)

Supporting: *Present address: Department of Chemistry, Texas Christian University, Box 298860, For Worth, TX76129, U.S.A