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潘库溴铵在婴儿、儿童和成年人的要到动力学

薛富善, 罗来葵, 孙伯华, 邹勤

  

  1. 中国医学科学院 中国协和医科大学 整形外科医院, 北京 100041

  • 收稿日期:1996-06-17 修回日期:1997-05-27 出版日期:1997-12-15 发布日期:1997-12-15

The Pharmacokinetics of Pancuronium in Infants, Children and Adults

Fu-Shan Xue, Lai-Kui Luo, Bai-Hua Sun, Qin Zou

  

  1. Department of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100041

  • Received:1996-06-17 Revised:1997-05-27 Online:1997-12-15 Published:1997-12-15

摘要:

研究观察年龄对潘库溴铵药代动力学的影响。选择24例施择期整形外科手术的患者, 根据年龄分成三组:1组为5例婴幼儿, 年龄0.75~2.95; 2组为13例儿童, 年龄4~14; 3组为6例成人, 年龄16~27岁。静注潘库溴铵100 μg/kg后用改良荧光法测定其血浓度。潘库溴铵的体内过程能用二室开放模型完整描述, 年龄愈小, 分布容积愈大, 血浆清除率愈高, 潘库溴铵的血药浓度愈低。V1(中央室分布容积)V2 (周边室分布容积)Vdss(稳态分布容积)Cl(血浆清除率)AUC(曲线下面积)在三组间有明显差别。1组的T1/2βMRT明显比23组长, T1/2αK21在三组间无明显差别。

关键词: 潘库溴铵, 药代动力学, 年龄

Abstract:

In order to determine the effect of age on the pharmacokinetics of pancuronium, twenty-four patients undergoing elective plastic surgery were studied. The patients were divided into three groups by their ages: Group 1-infants, 0.75 to 2.95 years (n = 5); Group 2-children, 4 to 14 years (n = 13); and Group 3-adults, 16 to 27 years (n = 6). After administered a bolus of pancuronium 100 μg/kg, an improved fluorimetric assay was used to measure the plasma concentrations of pancuronium. The pharmacokinetics of pancuronium may be best described mathematically by a two-compartment open model in all patients. The younger the patients, the larger the distribution volumes, the higher the Cl, and the lower the plasma concentrations of pancuronium. There were significant differences among the three groups regarding V1, V2, Vdss, Cl, AUC. T1/2β, MRT in Group 1 were longer than those in Groups 2 and 3. T1/2α and K21 were not significantly different among the three groups.

Key words: Pancuronium, Pharmacokinetics, Age

Supporting: *This study is supported by the scientific research fund of Chinese Academy of Medical Sciences and Peking Union Medical College.