樟叶胡椒中环氧环己烯类化合物的研究

樟叶胡椒中环氧环己烯类化合物的研究

马迎, 韩桂秋

北京医科大学天然药物与仿生药物国家重点实验室北京 100083

收稿日期:1992-12-17 修回日期:1993-05-29 出版日期:1993-12-15 发布日期:1993-12-15

Cyclohexene Epoxides from Piper polysyphorum

Ying Ma, Gui-Qiu Han

National Laboratory of Natural and Biomimetic Drugs; Beijing Medical University; Beijing 100083

Received:1992-12-17 Revised:1993-05-29 Online:1993-12-15 Published:1993-12-15

摘要/Abstract

摘要： 从樟叶胡椒中分离到三个新的环氧环己烯类化合物, 樟叶环氧素 A, 樟叶环氧素 B 和樟叶环氧素 C。另有一个已知化合物巴豆环氧素。经光谱鉴定, 其结构分别为1S, 2S, 3R, 6S-1-苯甲酰氧亚甲基-2-羟基-3-苯甲酰氧基-1, 6-环氧环己-4-烯(1), rel-1S, 2R, 5S, 6R-1苯甲酰氧亚甲基-2-羟基-5-苯甲酰氧基-1, 6-环氧环己-3-烯(2)和 rel-1S, 2R, 5S, 6R-2-羟基-3-苯甲酰氧亚甲基-5-苯甲酰氧基-1, 6-环氧环己-4-烯(3)。化合物(1), (2), (3)为首次从天然资源中分离得到。

关键词: 樟叶胡椒, 环氧环己烯, 樟叶环氧素 A, 樟叶环氧素 B, 樟叶环氧素 C

Abstract: Three new cyclohexene epoxides, polysyphoside A, B and C, along with a known compound crotepoxide (4), were isolated from Piper polysyphorum C. DC. Based on spectroscopic analysis, their structures were established as 1-benzoyloxymethylene-2-hydroxy-3-benzoyloxy-1, 6- epoxycyclohex-4-ene (1), 1-benzoyloxymethylene-2-hydroxy-5-benzoyloxy-1, 6-epoxycyclohex-3-ene (2) and 2-hydroxy-3-benzoyloxymethylene-5-benzoyloxy-1, 6-epoxycyclohex-3-ene (3), respectively. It was the first time that(1), (2) and (3) had been isolated from a natural source.

Key words: Piper polysyphorum, Cyclohexene epoxides, Polysyphoxide A, Polysyphoxide B, Polysyphoxide C

Supporting:

马迎, 韩桂秋. 樟叶胡椒中环氧环己烯类化合物的研究[J]. .

Ying Ma, Gui-Qiu Han. Cyclohexene Epoxides from Piper polysyphorum[J]. .