赤芝孢子粉三萜化学成分研究

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赤芝孢子粉三萜化学成分研究

陈若芸, 于德泉

中国医学科学院药物研究所, 北京 100050

收稿日期:1992-06-08 修回日期:1993-05-29 出版日期:1993-12-15 发布日期:1993-12-15

Studies on the Triterpenoid Constituents of the Spores from Ganoderma lucidum Karst

Ruo-Yun Chen, De-Quan Yu

Institute of Materia Medica; Chinese Academy of Medical Sciences; Beijing 100050

Received:1992-06-08 Revised:1993-05-29 Online:1993-12-15 Published:1993-12-15

摘要/Abstract

摘要： 从赤芝孢子粉(Ganoderma lucidum Karst)酯溶部分分离得到五种三萜类化合物经理化常数和光谱(UV, IR, MS, ¹H 和¹³C NMR)分析分别鉴定为赤芝孢子酸 A (ganosporeric acid A, I), ganoderic acid B (II), ganderic acid C (III), ganoderic acid E (IV), ganodermanontriol (V)。其中赤芝孢子酸 A 是新化合物, 其余均为首次从赤芝孢子粉中得到。经药理实验表明赤芝孢子酸 A对 CCl4和 GaNI 引起的小鼠转氨酶升高有降低作用, 对丙酸杆菌引起的小鼠免疫性肝损伤有保护作用。

关键词: 赤芝孢子粉, 赤芝孢子酸 A, Ganoderic acid B.C.E, Ganodermanontriol

Abstract: Five compounds were isolated from the ether-soluble fraction of the spores of Ganoderma lucidum. On the basis of their chemical properties and spectral data(MS, UV, IR, ¹H and ¹³C NMR), they were identified as 3, 7, 11, 12, 15, 23-hexaoxo-5α-lanosta-8-en-26-oic acid (I), ganoderic acid B (II), C (III), D (IV)and ganodermanontriol(Ⅴ).Compound I is a new natural product, named ganosporeric acid A. Compounds II, III, IV and V are known compounds and were obtained for the first time from the spores of Ganoderma lucidum.Pharmacological experiments showed that ganosporeric acid A has an activity for lowering the levels GPT in mice with liver injury by CCl4 and GaNI and exhibits heptoprotective effects.

Key words: Spores of Ganoderma lucidum, Ganosporeric acid A, Ganoderic acid B, C, E, Ganodermanontriol

Supporting:

陈若芸, 于德泉. 赤芝孢子粉三萜化学成分研究[J]. .

Ruo-Yun Chen, De-Quan Yu . Studies on the Triterpenoid Constituents of the Spores from Ganoderma lucidum Karst[J]. .