银耳多糖对躯体性应激小鼠的免疫功能的影响

银耳多糖对躯体性应激小鼠的免疫功能的影响

崔金莺, 林志彬

北京医科大学药理学教研室, 北京 100083

收稿日期:1992-03-24 修回日期:1992-08-30 出版日期:1992-12-15 发布日期:1992-12-15

Effects of Tremella Polysaccharide on Immune Function of Physically-Stressed Mice

Jin-Ying Cui, Zhi-Bin Lin

Department of Phamarcology, Beijing Medical University, Beijing 100083

Received:1992-03-24 Revised:1992-08-30 Online:1992-12-15 Published:1992-12-15

摘要/Abstract

摘要： 以强迫小鼠在冷水14±1 ºC中游泳的方法造成躯体性应激模型, 观察此时免疫功能的变化及银耳多糖(TP)对它的影响。结果指出, 应激可使羊红细胞(SRBC)致敏小鼠脾脏的空斑形成细胞(PFC)减少, 使二硝基氯苯(DNCB)所致迟发型皮肤过敏反应(DCH)和刀豆素A (Con A) 诱导的脾淋巴细胞增殖反应减弱。PFC的最大减少见于应激的9-12日。切除双侧肾上腺不影响应激所致PFC减少。每日口服TP (200, 400 mg/kg) 8-14日能使应激所致上述免疫反应降低明显恢复。

关键词: 银耳多糖, 躯体性应激, 空斑形成细胞, 迟发型皮肤过敏反应, 淋巴细胞增殖反应

Abstract: An immunosuppressive animal model induced by physical stress that forced mice to swim in cold water (14±1 ºC) and the restorative effect of Tremella polysac charide (TP) on the suppressed immune function by stress were studied in mice. It was found that the spleen plaque forming cell (PFC) response to sheep red blood cells, delayed cutaneous hypersensitivity (DCH) induced by dinitrochlorobenzene and the lymphocyte proliferation stimulated by concanavalin A (Con A) were significantly decreased in stressed mice. In addition. The maximal decrease of PFC was reached in 9-12 days after stress. A-drenolectomy could not affect the decrease of PFC in stressed mice. TP(200, 400 mg/kg) ig for 8-14 days significantly restored the PFC.DCH and lymphocyte proliferation to nor- mal level in stressed mice.

Key words: Tremella polysaccharide, Physical stress, Plaque forming cell (PFC), Delayed cutaneous hypersensitivity (DCH), Lymphocyte proliferation

Supporting:

崔金莺, 林志彬. 银耳多糖对躯体性应激小鼠的免疫功能的影响[J]. .

Jin-Ying Cui, Zhi-Bin Lin. Effects of Tremella Polysaccharide on Immune Function of Physically-Stressed Mice[J]. .