颅通定-聚离子复合凝胶释放体系初探

颅通定-聚离子复合凝胶释放体系初探

谢世杉, 刘向军, 张宇新, 张晋琳, 张德云, 王延林, 李芚, 倪丹

1. 中国科学院成都有机化学研究所成都 610015;
2. 华西医科大学药学院; 华西医科大学药学院成都 610041

收稿日期:1991-11-18 修回日期:1992-08-27 出版日期:1992-12-15 发布日期:1992-12-15

A Preliminary Study of Rotundine-Polyion Complex Release System

Shi-Shen Xie, Xiang-Jun Liu, Yu-Xin Zhang, Jin-Lin Zhang, De-Yun Zhang, Yan-Lin Wang, Dun Li, Dan Ni

1. Chengdu Institute of Organic Chemistry; Chinese Academy of Sciences; Chengdu 610015;
2. School of Pharmacy; West China University of Medical Sciences; Chengdu 610041

Received:1991-11-18 Revised:1992-08-27 Online:1992-12-15 Published:1992-12-15

摘要/Abstract

摘要： 一种颅通定-聚离子复合凝胶释放体系, 通过含药的壳多糖醋酸溶液使成球, 然后再用羧甲基葡甘聚糖溶液粒面复合两步法制得。平均粒径(d) 1.38-1.53 mm, 药含量可达62.8%。体外释放试验表明, 在人工胃液中药物半释放T50为45分钟, 总释放达4小时, 但在人工肠液中4小时仅释放药60%左右。考察了各种影响药物释放的因素。

关键词: 颅通定, 聚离子复合凝胶, 壳多糖, 羧甲基葡甘聚糖, 药物释放

Abstract: A rotundine-polyion complex (PIC) release system was prepared first by granulation of rotundine containing chitosan acetate solution and then by complexing with carboxymethyl glucomannan (CMGM) solution on the granular surface. The granules have an average diameter of 1.38~1.53 mm and the drug content reaches 62.89%. The external release tests showed T50 to be 45 min and the total release time 4 h in an artificial gastric juice, while no more than 60% of the drug was released in the same period of time in an artificial intestinal fluid. The various factors affecting the external release were examined.

Key words: Rotundine, Polyion Complex, Chitosan, Konjac glucomannan, Drug release

Supporting:

谢世杉, 刘向军, 张宇新, 张晋琳, 张德云, 王延林, 李芚, 倪丹. 颅通定-聚离子复合凝胶释放体系初探[J]. .

Shi-Shen Xie, Xiang-Jun Liu, Yu-Xin Zhang, Jin-Lin Zhang, De-Yun Zhang, Yan-Lin Wang, Dun Li, Dan Ni. A Preliminary Study of Rotundine-Polyion Complex Release System[J]. .

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