N-(3',4',5'-三甲氧基肉桂酰)邻氨基苯甲酸对抗原诱发的离体豚鼠回肠收缩、大鼠肥大细胞脱颗粒及组胺释放的影响

N-(3',4',5'-三甲氧基肉桂酰)邻氨基苯甲酸对抗原诱发的离体豚鼠回肠收缩、大鼠肥大细胞脱颗粒及组胺释放的影响

马俊江, 斯拉甫, 林志彬

北京医科大学药理教研室北京100083

收稿日期:1991-11-05 修回日期:1992-03-10 出版日期:1992-06-15 发布日期:1992-06-15

Effects of N-(3', 4', 5'-Trimethoxycinnamoyl) ortho-Aminobenzoic Acid on Antigen-induced Contraction of Guinea-pig Ileum and the Degranulation of and Histamine Release from Mast Cells

Jun-Jiang Ma, La-Fu Si, Zhi-Bin Lin

Department of Pharmacology; Beijing Medical University; Beijing 100083

Received:1991-11-05 Revised:1992-03-10 Online:1992-06-15 Published:1992-06-15

摘要/Abstract

摘要： 实验证明 N-(3', 4', 5'-三甲氧基肉桂酰)邻氨基苯甲酸(TOA)管内浓度80 μg/ml 能明显抑制抗原诱发的主动致敏豚鼠离体回肠收缩。TOA 管内浓度25和50 μg/ml 能显著抑制亲同种细胞抗体介导的大鼠肠系膜肥大细胞脱颗粒和腹腔肥大细胞组胺释放。

关键词: 肉桂酰胺类, 回肠, 肥大细胞, 脱颗粒, 组胺

Abstract: N-(3', 4', 5'-Trimethoxycinnamoyl) ortho-aminobenzoic acid (TOA), at the concentration of 80 μg/ml, significantly inhibited the antigen-induced contraction of ileum isolated from the actively sensitized guinea-pig. At the concentrations of 25 and 50 μg/ml, TOA inhibited homocytotropic antibody-mediated degranulation of mast cells in the rat mesentery, and also inhibited anaphylactic histamine release from rat peritoneal mast cells.

Key words: Cinnamoyl amines, Ileum, Mast cells, Degranulation, Histamine

Supporting:

马俊江, 斯拉甫, 林志彬. N-(3',4',5'-三甲氧基肉桂酰)邻氨基苯甲酸对抗原诱发的离体豚鼠回肠收缩、大鼠肥大细胞脱颗粒及组胺释放的影响 [J]. .

Jun-Jiang Ma, La-Fu Si, Zhi-Bin Lin. Effects of N-(3', 4', 5'-Trimethoxycinnamoyl) ortho-Aminobenzoic Acid on Antigen-induced Contraction of Guinea-pig Ileum and the Degranulation of and Histamine Release from Mast Cells[J]. .

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