灵芝对高血压伴高血脂和脑血栓后遗症患者血液流变学的观察

灵芝对高血压伴高血脂和脑血栓后遗症患者血液流变学的观察

程彰华, 王珏英, 邵以德, 梁子钧, 宁益华, 白之娟, 董双, 叶玉蟾, 森昌夫, 黄维蓉

1. 上海医科大学药学院药理教研室, 上海 200032;
2. 上海医科大学生物物理教研室, 上海 200032;
3. 上海医科大学保健科, 上海 200032;
4. 和汉生药研究所, 日本, 东京都

收稿日期:1991-10-10 修回日期:1992-03-10 出版日期:1992-06-15 发布日期:1992-06-15

Effects of Lingzhi (Ganoderma lucidum) on Hemorrheology Parameters and Symptoms of Hypertensive Patients with Hyperlipidemia and Sequelae of Cerebral Thrombosis

Zhang-Hua Cheng, Jue-Ying Wang, Yi-De Shao, Zi-Jun Liang, Yi-Hua Ning, Zhi-Juan Bai, Shuang Dong, Yu-Chan Ye, Masao Mori, Wei-Rong Huang

1. Department of Pharmacology; School of Pharmacy; Shanghai Medical University; Shanghai 200032;
2. Department of Biophysics; Shanghai Medical University; Shanghai 200032;
3. Infirmary; Shanghai Medical University; Shanghai 200032;
4. Wakan Shoyaku Laboratory Co; Tokyo; Japan

Received:1991-10-10 Revised:1992-03-10 Online:1992-06-15 Published:1992-06-15

摘要/Abstract

摘要： 灵芝片110 mg, qid, 服药2周, 对高血压伴高血脂、脑血栓后遗症和冠心病等高血粘度病人33例进行血液流变学观察。结果表明, 灵芝片有改善血液流变性、降低血粘度作用, 因而对心脑血管疾病有减少血栓形成的效果。此外, 多数病人服用灵芝后有降压、镇静、催眠和改善头痛、眼花等症状的作用。

关键词: 灵芝, 血液流变学, 血栓形成

Abstract: The effects of Lingzhi (Ganoderma lucidum) on hemorrheology parameters and symptoms of hypertensive patients with hyperlipidemia, sequelae of cerebral thrombosis and coronary heart disease are studied. The Lingzhi extract was given to 33 patients (15 male, 18 female, 65±8 years old) in dosage of 110 mg qid po for 2 weeks. The blood viscosity was improved after treatment. The results showed that whole blood viscosity (at high shear rate and low shear rate) and plasma viscosity were significantly decreased(P<0.01). Lingzhi showed the effect of reducing blood pressure simultaneously. Several symptoms were also improved. However, there were no significant changes in haematocrit and erythrocyte sedimentation rate (P>0.05).In a few cases there occurred adverse reactions of palpitation and restlessness.

Key words: Ganoderma lucidum, Hemorrheology, Thrombosis

Supporting:

程彰华, 王珏英, 邵以德, 梁子钧, 宁益华, 白之娟, 董双, 叶玉蟾, 森昌夫, 黄维蓉. 灵芝对高血压伴高血脂和脑血栓后遗症患者血液流变学的观察[J]. .

Zhang-Hua Cheng, Jue-Ying Wang, Yi-De Shao, Zi-Jun Liang, Yi-Hua Ning, Zhi-Juan Bai, Shuang Dong, Yu-Chan Ye, Masao Mori, Wei-Rong Huang. Effects of Lingzhi (Ganoderma lucidum) on Hemorrheology Parameters and Symptoms of Hypertensive Patients with Hyperlipidemia and Sequelae of Cerebral Thrombosis[J]. .

[1]	陈香, 陶少林, 高峰*, 李英波, 钟建江. 高效液相色谱法测定大鼠血浆中灵芝酸单体T及其药动学考察[J]. , 2010, 19(3): 209-213.
[2]	薛彬彬, 郭晓宇, 车庆明^* . 大鼠灌胃灵芝总三萜后血浆中灵芝酸类成分的检测[J]. , 2008, 17(3): 236-240.
[3]	力弘, 贾永锋, 森昌夫, 张罗修. 灵芝对动物胶原蛋白性关节炎的作用[J]. , 2000, 9(1): 46-49.
[4]	贾永锋, 力弘, 森昌夫, 张罗修. 灵芝对小鼠巨噬细胞产生肿瘤坏死因子的影响[J]. , 1998, 7(1): 29-32.
[5]	王芳生, 蔡辉, 杨峻山^*, 张聿梅, 赵英举. 赤芝子实体中三萜化学成分的研究[J]. , 1997, 6(4): 192-197.
[6]	王福军, 张世玲. BM-13505抗栓作用及机理研究[J]. , 1995, 4(2): 67-74.
[7]	沈忆征, 李长龄, 王银叶, 郭小东, 韩桂秋. 血小板活化因子受体拮抗剂海风藤酮的特性:对血小扳活化因子体内、体外的特异性抑制作用[J]. , 1994, 3(1): 59-65.
[8]	何云庆, 李荣芷, 陈琪, 林志彬, 夏冬, 马莉. 灵芝免疫活性多糖的研究[J]. , 1992, 1(1): 79-81.