文冠果油的助眠作用研究

doi:10.5246/jcps.2025.12.082

中国药学(英文版) ›› 2025, Vol. 34 ›› Issue (12): 1092-1100.DOI: 10.5246/jcps.2025.12.082

文冠果油的助眠作用研究

姬宝凤¹, 张曦萌¹, 张朕僖¹^,^*(), 牟波²^,^*(), 杜权¹^,^*()

^1. 北京大学药学院天然药物及仿生药物全国重点实验室, 北京 100191
^2. 云南大学附属医院临床营养科, 云南昆明 650021

收稿日期:2025-09-02 修回日期:2025-10-06 接受日期:2025-10-28 出版日期:2025-12-31 发布日期:2025-12-31
通讯作者: 张朕僖, 牟波, 杜权

Sleep-promoting effects of X. sorbifolium oil

Baofeng Ji¹, Ximeng Zhang¹, Zhenxi Zhang¹^,^*(), Bo Mou²^,^*(), Quan Du¹^,^*()

¹ State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
² Department of Clinical Nutrition, Affiliated Hospital of Yunnan University, Kunming 650021, Yunnan, China

Received:2025-09-02 Revised:2025-10-06 Accepted:2025-10-28 Online:2025-12-31 Published:2025-12-31
Contact: Zhenxi Zhang, Bo Mou, Quan Du

摘要/Abstract

摘要：

文冠果(X. sorbifolia)是中国北方的一种区域性油料作物, 在历史上有着丰富的药用记载。文冠果油是来源于文冠果种籽的可食用植物油, 其一个显著的特点是含有丰富的神经酸。本研究神经酸在神经系统中的重要作用, 对文冠果油的助眠作用进行研究。利用食品级的“文冠籽油凝胶糖果”, 首先开展了人体试食试验, PSQI和ISI量表分析结果表明: 文冠果油对人类睡眠质量有积极的促进作用。进一步根据“国家市场监督管理总局”颁布的《保健食品功能检验与评价方法(2023年版)》中规定的“有助于改善睡眠检验方法”, 对文冠果油的助眠作用进行了动物研究, 包括“睡眠潜伏期实验”和 “延长睡眠时间实验”, 结果表明给予小鼠不同剂量的文冠果油灌胃,能将睡眠潜伏期缩短33%, 睡眠时间延长46%。更进一步利用视频监控方案, 分析了文冠果油对小鼠自然睡眠的影响, 发现给予文冠果油能提高小鼠的睡眠总时长。研究表明文冠果油具有良好的助眠作用。

关键词: 文冠果种籽油, 具有睡眠促进作用的植物油, 非药物睡眠促进作用

Abstract:

Xanthoceras sorbifolium Bunge (X. sorbifolia), a regionally significant oilseed crop indigenous to northern China, has long been recognized for its medicinal value. A distinguishing feature of X. sorbifolium oil is its high concentration of nervonic acid, a bioactive lipid essential for the development and optimal functioning of the nervous system. In the present study, the potential sleep-enhancing properties of X. sorbifolium oil were investigated. The research began with a human feeding trial, which demonstrated notable improvements in sleep quality. To further validate the findings, animal experiments were conducted in accordance with the standardized protocols outlined in the Methods for Functional Testing and Evaluation of Health Food. Using male ICR mice, hydrated chloral-induced sleep tests were performed to assess the effects of X. sorbifolium oil on sleep latency and duration. Results revealed that oral administration of the oil significantly reduced sleep latency by up to 33% and extended sleep duration by as much as 46% compared to the control group. Beyond the anesthetic-induced tests, a noninvasive video-based analysis was employed to evaluate sleep patterns under natural conditions, free from anesthetic interference. This approach further confirmed a marked increase in total sleep duration. In summary, our findings demonstrated that oral administration of X. sorbifolium oil conferred substantial sleep-promoting benefits, highlighting its potential as a natural therapeutic agent for enhancing sleep quality.

Key words: Seed kernel oil of Xanthoceras sorbifolium Bunge, Natural sleep-promoting oil, Non-drug sleep-promoting intervention

Supporting:

姬宝凤, 张曦萌, 张朕僖, 牟波, 杜权. 文冠果油的助眠作用研究[J]. 中国药学(英文版), 2025, 34(12): 1092-1100.

Baofeng Ji, Ximeng Zhang, Zhenxi Zhang, Bo Mou, Quan Du. Sleep-promoting effects of X. sorbifolium oil[J]. Journal of Chinese Pharmaceutical Sciences, 2025, 34(12): 1092-1100.

图/表 8

Figure 1. Profile of PSQI and ISI scores before and after the treatment of X. sorbifolium oil. PSQI and ISI scores before and after the treatment were calculated for the participant group. Statistical differences between the scores were analyzed and presented. Data are indicated as the mean ± SE. ***P < 0.001.

Figure 2. Dose optimization of X. sorbifolium oil treatment.

Figure 3. Schedule of X. sorbifolium oil administration and evaluation.

Figure 4. Effects of X. sorbifolium oil on sleep latency (a) and sleep duration (b). X. sorbifolium oil or saline was orally administrated to the experimental or control mice. The time of sleep latency and sleep duration was measured at four time points of the experiment, by means of anesthetic-induced sleep test. Data are presented as the mean ± SE. *P < 0.05; **P < 0.01; ***P < 0.001.

Figure 5. Dose effects of X. sorbifolium oil. Different doses of X. sorbifolium oil were orally administrated to the mice. Sleep latency (a) and sleep duration (b) were measured at four stages of the experiment. For each group, sleep latency and sleep duration were calculated and presented as the mean ± SE. Statistical difference was calculated relative to the control group; *P < 0.05.

Figure 6. An image of the video recorded.

Figure 7. Profile of sleep time and duration of the sleep fragments of the mice.

Figure 8. Effects of X. sorbifolium oil on total sleep time of the mice.

参考文献 17

[1]	Wang, H.D. Research progress on the chemical composition and comprehensive utilization of Xanthoceras sorbifolia Bunge. Chin. Wild Plant Resour. 1998, 17, 13–16.
[2]	Li, Z.L.; Luo, B.; Cheng, F.; Li, F.L.; Zou, K. Studies on the chemical constituents of the spermoderm of Xanthoceras sorbifolia Bunge. Lishizhen Med. Mater. Med. Res. 2007, 18, 1329–1330.
[3]	Zhang, S.; Zu, Y.G.; Fu, Y.J.; Luo, M.; Liu, W.; Li, J.; Efferth, T. Supercritical carbon dioxide extraction of seed oil from yellow horn (Xanthoceras sorbifolia Bunge.) and its anti-oxidant activity. Bioresour. Technol. 2010, 101, 2537–2544.
[4]	Liang, Q.; Fang, H.C.; Liu, J.N.; Zhang, B.H.; Bao, Y.; Hou, W.R.; Yang, K.Q. Analysis of the nutritional components in the kernels of yellowhorn (Xanthoceras sorbifolium Bunge) accessions. J. Food Compos. Anal. 2021, 100, 103925.
[5]	Yu, H.Y.; Fan, S.Q.; Bi, Q.X.; Wang, S.X.; Hu, X.Y.; Chen, M.Y.; Wang, L.B. Seed morphology, oil content and fatty acid composition variability assessment in yellow horn (Xanthoceras sorbifolium Bunge) germplasm for optimum biodiesel production. Ind. Crops Prod. 2017, 97, 425–430.
[6]	Venegas-Calerón, M.; Ruíz-Méndez, M.V.; Martínez-Force, E.; Garcés, R.; Salas, J.J. Characterization of Xanthoceras sorbifolium Bunge seeds: lipids, proteins and saponins content. Ind. Crops Prod. 2017, 109, 192–198.
[7]	Sassa, T.; Kihara, A. Metabolism of very long-chain fatty acids: genes and pathophysiology. Biomol. Ther. 2014, 22, 83–92.
[8]	Merrill, A.H.; Schmelz, E.M.; Wang, E.; Dillehay, D.L.; Rice, L.G.; Meredith, F.; Riley, R.T. Importance of sphingolipids and inhibitors of sphingolipid metabolism as components of animal diets. J. Nutr. 1997, 127, 830S–833S.
[9]	Kikas, P.; Chalikias, G.; Tziakas, D. Cardiovascular implications of sphingomyelin presence in biological membranes. Eur. Cardiol. 2018, 13, 42–45.
[10]	Amminger, G.P.; Schäfer, M.R.; Klier, C.M.; Slavik, J.M.; Holzer, I.; Holub, M.; Goldstone, S.; Whitford, T.J.; McGorry, P.D.; Berk, M. Decreased nervonic acid levels in erythrocyte membranes predict psychosis in help-seeking ultra-high-risk individuals. Mol. Psychiatry. 2012, 17, 1150–1152.
[11]	Kageyama, Y.; Kasahara, T.; Nakamura, T.; Hattori, K.; Deguchi, Y.; Tani, M.; Kuroda, K.; Yoshida, S.; Goto, Y.I.; Inoue, K.; Kato, T. Plasma nervonic acid is a potential biomarker for major depressive disorder: a pilot study. Int. J. Neuropsychopharmacol. 2018, 21, 207–215.
[12]	Lewkowicz, N.; Piątek, P.; Namiecińska, M.; Domowicz, M.; Bonikowski, R.; Szemraj, J.; Przygodzka, P.; Stasiołek, M.; Lewkowicz, P. Naturally occurring nervonic acid ester improves myelin synthesis by human oligodendrocytes. Cells. 2019, 8, 786.
[13]	Sargent, J.R.; Coupland, K.; Wilson, R. Nervonic acid and demyelinating disease. Med. Hypotheses. 1994, 42, 237–242.
[14]	Du, N.; Wang, L.E.; Shi, X.R.; Cui, X.Y.; Zhang, F.; Zhang, Y.H. Augmentative effect of tetrandrine on Pentobarbital hypnosis mediated by 5-HT_1A and 5-HT_2A/2Vreceptors in mice. J. Chin. Pharm. Sci. 2008, 17, 192–196.
[15]	Song, W.T.; Zhang, K.; Xue, T.; Han, J.R.; Peng, F.D.; Ding, C.G.; Lin, F.; Li, J.J.; Sze, F.T.A.; Gan, J.W.; Chen, X.Y. Cognitive improvement effect of nervonic acid and essential fatty acids on rats ingesting Acer truncatum Bunge seed oil revealed by lipidomics approach. Food Funct. 2022, 13, 2475–2490.
[16]	Victorri-Vigneau, C.; Dailly, E.; Veyrac, G.; Jolliet, P. Evidence of zolpidem abuse and dependence: results of the French Centre for Evaluation and Information on Pharmacodependence (CEIP) network survey. Br. J. Clin. Pharmacol. 2007, 64, 198–209.
[17]	Lichstein, K.L.; Nau, S.D.; Wilson, N.M.; Aguillard, R.N.; Lester, K.W.; Bush, A.J.; McCrae, C.S. Psychological treatment of hypnotic-dependent insomnia in a primarily older adult sample. Behav. Res. Ther. 2013, 51, 787–796.

文冠果油的助眠作用研究

Sleep-promoting effects of X. sorbifolium oil

RichHTML

可视化

摘要/Abstract

引用本文

使用本文

图/表 8

参考文献 17

相关文章 0

编辑推荐

Metrics

本文评价