早期肠外营养对极低出生体重儿支气管肺发育不良发生的影响研究

doi:10.5246/jcps.2025.04.029

中国药学(英文版) ›› 2025, Vol. 34 ›› Issue (4): 385-391.DOI: 10.5246/jcps.2025.04.029

早期肠外营养对极低出生体重儿支气管肺发育不良发生的影响研究

涂颖秋¹, 贾家丽¹, 胥甜甜¹, 赖敏芳¹, 王芳²^,^*()

^1. 南昌大学第一附属医院药学部, 江西南昌 330000
^2. 南昌大学第一附属医院儿科, 江西南昌 330000

收稿日期:2024-10-15 修回日期:2024-11-18 接受日期:2024-12-07 出版日期:2025-05-02 发布日期:2025-05-02
通讯作者: 王芳

Impact of early parenteral nutrition on the development of bronchopulmonary dysplasia in very-low-birth-weight infants

Yingqiu Tu¹, Jiali Jia¹, Tiantian Xu¹, Minfang Lai¹, Fang Wang²^,^*()

¹ Department of Pharmacy, the First Affiliated Hospital of Nanchang University, Nanchang 330000, Jiangxi, China
² Department of Pediatrics, the First Affiliated Hospital of Nanchang University, Nanchang 330000, Jiangxi, China

Received:2024-10-15 Revised:2024-11-18 Accepted:2024-12-07 Online:2025-05-02 Published:2025-05-02
Contact: Fang Wang
Supported by:
Science and Technology Program Project of Jiangxi Provincial Health Commission (Grant No. 202210200).

摘要/Abstract

摘要：

本研究旨在主要对胎龄<34周极低出生体重儿生后28天内肠外营养对支气管肺发育不良(BPD)的影响因素进行研究分析。回顾性收集2021年1月至2021年12月出生并于生后24 h内转入新生儿重症监护病房、胎龄<34周、极低出生体重儿作为研究对象, 包括14例非BPD患儿和20例BPD患儿。比较两组患儿住院期间的临床资料。研究表明, BPD组患儿第1天热氮比均值(105.44 ± 26.67), 非BPD组患儿第1天热氮比均值为(146.81 ± 37.04), 两组患儿第1天热氮比方面存在显著性统计学差异(P = 0.04 < 0.05), 其余指标均无统计学差异。因此发现, 需要更多样本量证实热氮比与BPD发生的相关性。

关键词: 极低出生体重儿, 肠外营养, 支气管肺发育不良, 热氮比, 脂肪乳剂, 液体摄入量

Abstract:

The aim of this study is to analyze factors influencing the development of bronchopulmonary dysplasia (BPD) within 28 d after birth in very-low-birth-weight (VLBW) infants with a gestational age of less than 34 weeks who were receiving early parenteral nutrition. Data were retrospectively collected from infants born between January and December 2021, who were admitted to the neonatal intensive care unit within 24 h of birth, had a gestational age of less than 34 weeks, and were classified as VLBW. The study included 14 cases without BPD and 20 cases with BPD, and it compared clinical data during hospitalization between these two groups. On the 1st day of life, the BPD group had a nitrogen-to-calorie ratio of 105.44 ± 26.67, while the non-BPD group had a ratio of 146.81 ± 37.04. This difference was statistically significant, with a P-value of 0.04, indicating a potential association between the nitrogen-to-calorie ratio and the development of BPD. However, no significant differences were observed in other clinical indicators between the two groups. These findings suggested that a larger sample size was needed to further explore and confirm the correlation between the nitrogen-to-calorie ratio and the risk of developing BPD in this population.

Key words: Very-low-birth-weight infants, Parenteral nutrition, Bronchopulmonary dysplasia, Nitrogen-to-calorie ratio, Fluid intake, Lipid emulsion

Supporting:

涂颖秋, 贾家丽, 胥甜甜, 赖敏芳, 王芳. 早期肠外营养对极低出生体重儿支气管肺发育不良发生的影响研究[J]. 中国药学(英文版), 2025, 34(4): 385-391.

Yingqiu Tu, Jiali Jia, Tiantian Xu, Minfang Lai, Fang Wang. Impact of early parenteral nutrition on the development of bronchopulmonary dysplasia in very-low-birth-weight infants[J]. Journal of Chinese Pharmaceutical Sciences, 2025, 34(4): 385-391.

图/表 4

Table 1. Comparison of clinical characteristics between BPD and non-BPD groups.

Table 2. Comparison of clinical characteristics between the two adjusted groups.

Table 3. Comparison of early nutrient intake between BPD and non-BPD groups.

Figure 1. Average weight growth curve of the child within 28 d after birth.

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早期肠外营养对极低出生体重儿支气管肺发育不良发生的影响研究

Impact of early parenteral nutrition on the development of bronchopulmonary dysplasia in very-low-birth-weight infants

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