Emodin and shikonin (quinones): an overview of their chemistry, plant sources, pharmacology and cytotoxic activities against lung cancer

doi:10.5246/jcps.2020.01.001

中国药学(英文版) ›› 2020, Vol. 29 ›› Issue (1): 1-12.DOI: 10.5246/jcps.2020.01.001

• 【综述】 • 下一篇

Emodin and shikonin (quinones): an overview of their chemistry, plant sources, pharmacology and cytotoxic activities against lung cancer

Eric Wei Chiang Chan^1*, Chen Wai Wong¹, Siu Kuin Wong², Yew Woh Hui², Joash Ban Lee Tan³

1. Faculty of Applied Sciences, UCSI University, 56000 Cheras, Kuala Lumpur, Malaysia
2. Xiamen University Malaysia, Bandar Sunsuria, 43900 Sepang, Selangor, Malaysia
3. School of Science, Monash University Malaysia, Bandar Sunway, 47500 Subang Jaya, Selangor, Malaysia

收稿日期:2019-10-13 修回日期:2019-11-04 出版日期:2020-01-21 发布日期:2019-11-23
通讯作者: Tel.: +60-3-9101-8880, E-mail: chanwc@ucsiuniversity.edu.my, erchan@yahoo.com
作者简介:Dr. Eric Chan, Associate Professor at the Faculty of Applied Sciences, UCSI University, Kuala Lumpur, Malaysia, obtained his PhD (Natural Product Chemistry) from Monash University Malaysia in 2009. To date, Dr. Eric Chan has 88 publications in international refereed journals with 66 (5 in JCPS) as the lead author. His publications have received more than 1289 citations in Scopus and 2716 citations in Google Scholar. He was one of the Top 5 Competitors of the Elsevier Green and Sustainable Chemistry Challenge 2015, out of 500 proposals submitted globally. In April 2016, he presented his proposal at the Green and Sustainable Chemistry Conference in Berlin, Germany. In the same month, he was awarded the Promising Researcher Award by UCSI University.

Emodin and shikonin (quinones): an overview of their chemistry, plant sources, pharmacology and cytotoxic activities against lung cancer

Eric Wei Chiang Chan^1*, Chen Wai Wong¹, Siu Kuin Wong², Yew Woh Hui², Joash Ban Lee Tan³

1. Faculty of Applied Sciences, UCSI University, 56000 Cheras, Kuala Lumpur, Malaysia
2. Xiamen University Malaysia, Bandar Sunsuria, 43900 Sepang, Selangor, Malaysia
3. School of Science, Monash University Malaysia, Bandar Sunway, 47500 Subang Jaya, Selangor, Malaysia

Received:2019-10-13 Revised:2019-11-04 Online:2020-01-21 Published:2019-11-23
Contact: Tel.: +60-3-9101-8880, E-mail: chanwc@ucsiuniversity.edu.my, erchan@yahoo.com
About author:Dr. Eric Chan, Associate Professor at the Faculty of Applied Sciences, UCSI University, Kuala Lumpur, Malaysia, obtained his PhD (Natural Product Chemistry) from Monash University Malaysia in 2009. To date, Dr. Eric Chan has 88 publications in international refereed journals with 66 (5 in JCPS) as the lead author. His publications have received more than 1289 citations in Scopus and 2716 citations in Google Scholar. He was one of the Top 5 Competitors of the Elsevier Green and Sustainable Chemistry Challenge 2015, out of 500 proposals submitted globally. In April 2016, he presented his proposal at the Green and Sustainable Chemistry Conference in Berlin, Germany. In the same month, he was awarded the Promising Researcher Award by UCSI University.

摘要/Abstract

摘要：

Emodin and shikonin are quinones that are commonly found in the roots of plant species of the families Polygonaceae and Boraginceae, respectively. They have a wide spectrum of bioactivities, including anti-cancer properties. This overview on the cytotoxic properties of emodin and shikonin is focused on lung cancer, the leading cause of cancer death in the world. In emodin, the −OH groups at C1 and C3 positions, while in shikonin, the −OH groups of the naphthazarin moiety and chiral side-chain, are important for their anti-tumour functions. Studies have shown that emodin and shikonin inhibit the growth of lung cancer cells by inducing apoptosis, autophagy, necrosis and early senescence, and by inhibiting proliferation, invasion, migration and metastasis. The cytotoxic activities are involved multiple molecular targets and signalling pathways. A clinical trial using shikonin to treat patients with late-stage lung cancer has been presented. Some future perspectives and research needs are suggested. Sources of information are from Google Scholar, PubMed, Science Direct, J-Stage, PubChem and CNKI.

关键词: Quinones, Emodin, Shikonin, Lung cancer cells, Clinical trial

Abstract:

Key words: Quinones, Emodin, Shikonin, Lung cancer cells, Clinical trial

中图分类号:

R284

Supporting:

Eric Wei Chiang Chan, Chen Wai Wong, Siu Kuin Wong, Yew Woh Hui, Joash Ban Lee T. Emodin and shikonin (quinones): an overview of their chemistry, plant sources, pharmacology and cytotoxic activities against lung cancer[J]. 中国药学(英文版), 2020, 29(1): 1-12.

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Emodin and shikonin (quinones): an overview of their chemistry, plant sources, pharmacology and cytotoxic activities against lung cancer

Emodin and shikonin (quinones): an overview of their chemistry, plant sources, pharmacology and cytotoxic activities against lung cancer

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