白藜芦醇衍生天然产物Polynapstilbenes A和B的合成研究

doi:10.5246/jcps.2019.09.057

中国药学(英文版) ›› 2019, Vol. 28 ›› Issue (9): 595-604.DOI: 10.5246/jcps.2019.09.057

• 【研究论文】 • 下一篇

白藜芦醇衍生天然产物Polynapstilbenes A和B的合成研究

蒋柏阳, 邱凌琪, 刘锦荣, 王翰轩, 董甦伟^*

北京大学药学院天然药物及仿生药物国家重点实验室; 化学生物学系, 北京 100191

收稿日期:2019-04-27 修回日期:2019-05-18 出版日期:2019-09-30 发布日期:2019-06-21
通讯作者: Tel.: +86-10-82805931, E-mail: dongs@hsc.pku.edu.cn
基金资助:
Peking University Health Science Center (Grant No. BMU20130354), State Key Laboratory of Natural and Biomimetic Drugs, and the National Recruitment Program of Global Youth Experts (1000 Plan).

Synthetic studies toward resveratrol-based natural products polynapstilbenes A and B

Baiyang Jiang, Lingqi Qiu, Jinrong liu, Hanxuan Wang, Suwei Dong^*

State Key Laboratory of Natural and Biomimetic Drugs; Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China

Received:2019-04-27 Revised:2019-05-18 Online:2019-09-30 Published:2019-06-21
Contact: Tel.: +86-10-82805931, E-mail: dongs@hsc.pku.edu.cn
Supported by:
Peking University Health Science Center (Grant No. BMU20130354), State Key Laboratory of Natural and Biomimetic Drugs, and the National Recruitment Program of Global Youth Experts (1000 Plan).

摘要/Abstract

摘要：

本文报导了一种区域选择性合成基于白藜芦醇的[C8-O-C-C-C7]二氢苯并呋喃天然产物骨架的方法, 并据此合成了天然产物Polynapstilbenes A和B的合成中间体。

关键词: 白藜芦醇, Polynapstilbenes A和B, 二氢苯并呋喃

Abstract:

Resveratrol-based natural products have received considerable attention as synthetic targets due to their versatile bioactivities and unique structures. Herein, we disclose our efforts toward the syntheses of polynapstilbenes A and B, which possess[C8-O-C-C-C7]-type dihydrobenzofuran skeleton that is distinctive compared with the other reported resveratrol-derived natural products. Our approach, featuring an acid-catalyzed conjugate addition followed by cyclization of para-quinone methides and phenols, affords two advanced intermediates that represents the dimethyl-protected aglycon of polynapstilbenes A and B.

Key words: Resveratrol, Polynapstilbenes A and B, Dihydrobenzofuran

中图分类号:

R914

Supporting:

蒋柏阳, 邱凌琪, 刘锦荣, 王翰轩, 董甦伟. 白藜芦醇衍生天然产物Polynapstilbenes A和B的合成研究[J]. 中国药学(英文版), 2019, 28(9): 595-604.

Baiyang Jiang, Lingqi Qiu, Jinrong liu, Hanxuan Wang, Suwei Dong. Synthetic studies toward resveratrol-based natural products polynapstilbenes A and B[J]. Journal of Chinese Pharmaceutical Sciences, 2019, 28(9): 595-604.

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白藜芦醇衍生天然产物Polynapstilbenes A和B的合成研究

Synthetic studies toward resveratrol-based natural products polynapstilbenes A and B

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