基于APICloud 的药物基因组用药指导信息的手机APP的设计与实现

doi:10.5246/jcps.2019.04.028

中国药学(英文版) ›› 2019, Vol. 28 ›› Issue (4): 276-283.DOI: 10.5246/jcps.2019.04.028

• 【药事管理与临床药学专栏】 • 上一篇下一篇

基于APICloud 的药物基因组用药指导信息的手机APP的设计与实现

陈敏^1,2, 姜锋³, 郑铭³, 阳丽梅¹, 高红瑾^1*

1. 福建省立医院药学部, 福建福州 350001
2. 福建医科大学省立临床医学院, 福建福州 350001
3. 福建省立医院老年医学科, 福建福州 350001

收稿日期:2018-12-15 修回日期:2019-03-23 出版日期:2019-04-30 发布日期:2019-04-06
通讯作者: Tel.: +86-0591-88216117, E-mail: 13763806058@163.com

Design and implementation of mobile APP for medication guidance related to pharmacogenomic based on APICloud platform

Min Chen^1,2, Feng Jiang³, Ming Zheng³, Limei Yang¹, Hongjin Gao^1*

1. Department ofPharmacy, Fujian Provincial Hospital, Fuzhou 350001, China
2. Fujian Provincial Clinical College of Fujian Medical University, Fuzhou 350001, China
3. Department of Geriatrics, Fujian Provincial Hospital, Fuzhou 350001, China

Received:2018-12-15 Revised:2019-03-23 Online:2019-04-30 Published:2019-04-06
Contact: Tel.: +86-0591-88216117, E-mail: 13763806058@163.com

摘要/Abstract

摘要：

开发药物基因组相关用药指导查询软件手机APP, 可以解决英文数据库阅读不方便, 纸质专业书籍信息更新缓慢和查询不便捷等问题。我们归纳提取http://www.pharmgkb.com中“Dosing Guidelines”项下的剂量调整信息, http://www.fda.gov/drugs里Science&Research项下“Table of Pharmacogenomic Biomarkers in Drug Labeling”项下相关药物标签中提及的药物基因组信息, 并参考权威论著相关基因指导用药信息, 利用SQLite构建用药指导信息库, 在APICloud软件开发平台上, 使用JavaScript编程自建一款基因指导用药的手机APP。本APP收录了目前研究较多、证据级别较高的精准医学药物197种, 覆盖了抗凝和抗血小板药物、一般抗肿瘤药和免疫抑制剂、靶向抗肿瘤药、抗精神病药、抗癫痫药、质子泵抑制剂等25类。使用者可以通过输入药品通用名的拼音首字母获取该药特定基因型的临床意义及用药指导信息。基于APICloud开发平台自建的精准医学药物治疗与用药指导查询系统的手机APP可为临床提供实用快捷的药学信息服务。

关键词: 药物基因组, 用药指导, 手机APP

Abstract:

The mobile APP for medication guidance related to pharmacogenomic is developed to solve various practical problems, such as inconvenient reading of English database, slow updating of paper reference books and lack of shortcut for access. We extracted the medication guidance information related to the pharmacogenomic from ‘Dosing Guidelines’ (http://www.pharmgkb.com), ´Table of Pharmacogenomic Biomarkers in Drug Labeling´ (http://www.fda.gov/drugs/scienceresearch) and relevant authoritative books. SQLite was used to build the medication guidance information database. We designed and implemented a mobile APP for medication guidance by JavaScript programming language. The APP contained 197 drugs that have been extensively studied and have high levels of evidence. It covered 25 categories, such as anticoagulant and antiplatelet drugs, general antitumor, immunosuppressant drugs, targeted antitumor drugs, antipsychotic drugs, antiepileptic drugs, and proton pump inhibitors and so on. Users can obtain clinical significance and guidance information related to the genotype of the drug by entering the pinyin initials of the generic name of the drug. The mobile APP for medication guidance related to pharmacogenomic based on APICloud could provide practical and convenient pharmaceutical information service for clinical use.

Key words: Pharmacogenomics, Medication guidance, Mobile APP

中图分类号:

R954

Supporting:

陈敏, 姜锋, 郑铭, 阳丽梅, 高红瑾. 基于APICloud 的药物基因组用药指导信息的手机APP的设计与实现[J]. 中国药学(英文版), 2019, 28(4): 276-283.

Min Chen, Feng Jiang, Ming Zheng, Limei Yang, Hongjin Gao. Design and implementation of mobile APP for medication guidance related to pharmacogenomic based on APICloud platform[J]. Journal of Chinese Pharmaceutical Sciences, 2019, 28(4): 276-283.

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基于APICloud 的药物基因组用药指导信息的手机APP的设计与实现

Design and implementation of mobile APP for medication guidance related to pharmacogenomic based on APICloud platform

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