Interaction study between Ocimum sanctum and Glimepiride (sulfonylurea derivative) in diabetic rats

doi:10.5246/jcps.2015.03.019

中国药学(英文版) ›› 2015, Vol. 24 ›› Issue (3): 156-163.DOI: 10.5246/jcps.2015.03.019

Interaction study between Ocimum sanctum and Glimepiride (sulfonylurea derivative) in diabetic rats

Mohd Fasih Ahmad¹, Raj K. Keservani^2*, D J Mani Babu¹

1. Department of Pharmacology, V. L. College of Pharmacy, Raichur, Karnataka 584103, India
2. School of Pharmaceutical Sciences, Rajiv Gandhi Proudyogiki Vishwavidyalaya, Bhopal (M.P.) 462036, India

收稿日期:2014-11-12 修回日期:2014-12-26 出版日期:2015-03-29 发布日期:2015-01-08
通讯作者: Tel.: +917897803904

Interaction study between Ocimum sanctum and Glimepiride (sulfonylurea derivative) in diabetic rats

Mohd Fasih Ahmad¹, Raj K. Keservani^2*, D J Mani Babu¹

1. Department of Pharmacology, V. L. College of Pharmacy, Raichur, Karnataka 584103, India
2. School of Pharmaceutical Sciences, Rajiv Gandhi Proudyogiki Vishwavidyalaya, Bhopal (M.P.) 462036, India

Received:2014-11-12 Revised:2014-12-26 Online:2015-03-29 Published:2015-01-08
Contact: Tel.: +917897803904

摘要/Abstract

摘要：

The present study was intended to discover the interaction between Ocimum sanctum (O. sanctum) and Glimepiride, a sulfonylurea derivative used in the treatment of type-2 diabetes, in diabetic rats to suggest an alteration in the dose of Glimepiride in case of hypoglycaemia. LD₅₀ studies for the aqueous extract of O. sanctum leaf were carried out in albino mice up to the dose level of 2000 mg/kg. O. sanctum atlow, medium and high doses (100, 200 and 400 mg/kg, per oral), respectively and Glimepiride ½ (half) therapeutic dose, therapeutic dose and 2 time therapeutic dose (0.036, 0.072 and 0.144 mg/200 g, per oral) were selected. After the treatment with O. sanctum and Glimepiride as single doses and in various combinations of these two drugs in streptozotocin-induced diabetic rats serum glucose levels in all the groups were analysed by the glucose oxidase-peroxidasemethod. When administered alone as single doses both aqueous extract of O. sanctum leaf and Glimepiride produced a significant anti-diabetic effect in diabetic rats. The anti-diabetic effect observed with combination of aqueous extract of O. sanctum leaf and Glimepiride was significant and more when compared to either of the drugs given alone. There was a definite interaction that necessitates dose readjustment of Glimepiride and further glucose levels are to be frequently monitored to avoid complication of hypoglycemic condition with aqueous extract of O. sanctum leaf and Glimepiride combination.

关键词: Herb-drug interaction, Ocimum sanctum, Glimepiride, Type-2 diabetes

Abstract:

Key words: Herb-drug interaction, Ocimum sanctum, Glimepiride, Type-2 diabetes

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Mohd Fasih Ahmad, Raj K. Keservani, D J Mani Babu. Interaction study between Ocimum sanctum and Glimepiride (sulfonylurea derivative) in diabetic rats[J]. 中国药学(英文版), 2015, 24(3): 156-163.

Mohd Fasih Ahmad, Raj K. Keservani, D J Mani Babu. Interaction study between Ocimum sanctum and Glimepiride (sulfonylurea derivative) in diabetic rats[J]. Journal of Chinese Pharmaceutical Sciences, 2015, 24(3): 156-163.

参考文献

[1] Prasad, K.P.R.C.; Tharangani, P.G.D.; Samaranayake, C.N. J. Psychopharmacol. 2009, 23, 216-219.

[2] Gohil, K.J.; Patel, J.A. Indian J. Pharmacol. 2007, 39, 129-139.

[3] Phillip, M.P.; Damodaran, N.P. 1985, 29, 49-56.

[4] Kothari, S.K.; Bhattacharya, A.K.; Ramesh, S. J. Chromatogr. 2004, 1054, 67-72.

[5] Sukari, M.A.; Rahmani, M.; Lee, G.B. Fitoterpia. 1995, 66, 552-553.

[6] Brophy, J.J.; Goldsack, R.J.; Clarkson, J.R. J. Essent. Oil. Res. 1993, 5, 459-461.

[7] Nadkarni, G.B.; Patwardhan, V.A. Curr. Sci. 1952, 91, 68-69.

[8] Singh, S.; Majumdar, D.K.; Yadav, M.R. Indian J. Exp. Biol. 1996, 34, 1212-1215.

[9] Bhattathiry, M.P. 2011, Hinduism.about.com.

[10] Jeba, R.C.; Vaidyanathan, R.; Rameshkumar, G. Intl. J. Pharm. Biomed. Res. 2011, 2, 33-38.

[11] Singh, N. DRDO, Delhi, India on 3-7.

[12] Madhuri, S. Ph.D. thesis, Rani Durgavati Vishwa Vidyalaya, Jabalpur, MP, India. 2008.

[13] Madhuri, S.; Govind, P. Biomedicine. 2010, 5, 57-62.

[14] Godhwani, S.; Godhwani, J.L.; Vyas, D.S. J. Ethnopharmacol. 1988, 24, 193-198.

[15] Mondal, S.; Mirdha, B.R.; Mahapatra, S.C. Indian J. Physiol. Pharmacol. 2009, 53, 291-306.

[16] Karthikeyan, K.; Gunasekaran, P.; Ramamurthy, N.; Govindasamy, S. Pharm. Biol. 1999, 37, 285-290.

[17] Khan, V.; Najmi, A.K.; Mohd, A.; Mohd, A.; Mohd, M.; Pillai, K.K. J. Pharm. Biol. Sci. 2012, 4, 27-42.

[18] Nim, D.K; Shankar, P.; Chaurasia, R.; Goel, B.; Dixit, K.R. Int. J. Pharm. Biol. Sci. 2013, 4, 699-706.

[19] Prakash, P. Indian J. Physiol. Pharmacol. 2005, 49, 125-131.

[20] Inamdar, N.; Edalat, S.; Kotwal, V.B.; Pawar, S. Int. J. Green Pharm. 2008, 2, 2-8.

[21] Chavez, M.L. Inet CE, 2005, 9, 1-30.

[22] Kuhn, M.A. Critical Care Nurse. 2002, 22, 22-35.

[23] Triplitt, C. Diabet Spect. 2006, 19, 202-211.

[24] http://www.motherherbs.com/ocimum-sanctum-extract.html. Access date 5/12/2009.

[25] Kritikar, K.R.; Basu, B.D. Period. Exp. Book Agen. 1991, 3.

[26] Satyavati, C.R.V.; Raina, M.K.; Sharma, M. ICMR 1976, 1.

[27] Aggarwal, P.; Rai, V.; Singh, R.B. Int. J. Clin. Pharmacol. Ther. 1996, 34, 406-409.

[28] http://www.herbalcureindia.com/herbs/ocimum-sanctum.htm. Access date 2/12/2009.

[29] Kokate, C.K.; Vallabh, P. New Delhi. 1994, 4, 110-111.

[30] Mallikeswari, R. Indian Drugs. 2004, 41, 661-664.

[31] Trease, G.E.; Evans, M.C. Bailliare Tindall, London. 1983, 12, 193 and 336.

Interaction study between Ocimum sanctum and Glimepiride (sulfonylurea derivative) in diabetic rats

Interaction study between Ocimum sanctum and Glimepiride (sulfonylurea derivative) in diabetic rats

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