帕瑞昔布超前镇痛有效缓解妇科门诊手术术后疼痛的随机对照研究

doi:10.5246/jcps.2014.09.084

中国药学(英文版) ›› 2014, Vol. 23 ›› Issue (9): 654-659.DOI: 10.5246/jcps.2014.09.084

帕瑞昔布超前镇痛有效缓解妇科门诊手术术后疼痛的随机对照研究

李春晶¹, 于小兰², 王东信^1*, 曲元¹, 刘佳³, 穆东亮¹

1. 北京大学第一医院麻醉科, 北京 100034
2. 北京大学第一医院计划生育中心, 北京 100034
3. 北京大学第一医院妇产科手术室, 北京 100034

收稿日期:2014-03-24 修回日期:2014-05-12 出版日期:2014-09-23 发布日期:2014-05-15
通讯作者: Tel.: 86-10-13910731903

Parecoxib pretreatment effectively relieved pain after ambulatory gynecological surgery: a randomized controlled trial

Chunjing Li¹, Xiaolan Yu², Dongxin Wang^1*, Yuan Qu¹, Jia Liu³, Dongliang Mu¹

1. Departments of Anesthesiology and Critical Care Medicine, Peking University First Hospital, Beijing 100034, China
2. Department of Gynecology planning care ward, Peking University First Hospital, Beijing 100034, China
3. Gynecological Operating Center, Peking University First Hospital, Beijing 100034, China

Received:2014-03-24 Revised:2014-05-12 Online:2014-09-23 Published:2014-05-15
Contact: Tel.: 86-10-13910731903

摘要/Abstract

摘要：

帕瑞昔布超前镇痛在妇科门诊手术后疼痛治疗的作用一直没有完全阐明。本研究目的是观察帕瑞昔布超前镇痛是否能够减少妇科门诊手术后疼痛。200名准备接受妇科门诊手术的女患者随机分成两组: 试验组在麻醉诱导前30分钟静脉给予40 mg帕瑞昔布, 对照组给予生理盐水。用VAS评分系统(视觉模拟评分系统, 0 mm = 无痛, 100 mm = 最痛)做疼痛评分。帕瑞昔布组疼痛评分明显低于对照组; 帕瑞昔布组术中低氧血症发生率也明显降低; 术毕恢复到睁眼和能够回忆起出生日期的时间也明显缩短。帕瑞昔布组患者满意度也远远大于对照组。

关键词: 帕瑞昔布, 术后疼痛, 门诊手术, 妇科

Abstract:

Although parecoxib plays an important role in pain management after ambulatory gynecological surgery, its exact effect remains to be fully elucidated. In the present study, we aimed to investigate the effect of parecoxib pretreatment in reducing pain intensity after ambulatory gynecological surgery. A total of 200 female patients who were scheduled to selective ambulatory gynecological surgery were randomly divided into two groups. Patients in the control group received normal saline as placebo, whereas 40 mg parecoxib was given to the patients in the parecoxib group 30 min prior to anesthesia induction. Visual analoguescore (0 mm = no pain, and 100 mm = most severe pain) was used to evaluate postoperative pain severity. Pain scores were significantly lower in the parecoxib group than those in the control group after surgery. Compared with the control group, the incidence of intraoperative hypoxemia was significantly lower, and the recovery time from end of anesthesia to eye opening and birth date recollection were significantly shorter in the parecoxib group. Patients in the parecoxib group also had significantly improved overall satisfaction than those in the control group.

Key words: Parecoxib, Postoperative pain, Ambulatory surgery, Gynecology

中图分类号:

R711

Supporting:

李春晶, 于小兰, 王东信, 曲元, 刘佳, 穆东亮. 帕瑞昔布超前镇痛有效缓解妇科门诊手术术后疼痛的随机对照研究[J]. 中国药学(英文版), 2014, 23(9): 654-659.

Chunjing Li, Xiaolan Yu, Dongxin Wang, Yuan Qu, Jia Liu, Dongliang Mu. Parecoxib pretreatment effectively relieved pain after ambulatory gynecological surgery: a randomized controlled trial[J]. Journal of Chinese Pharmaceutical Sciences, 2014, 23(9): 654-659.

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帕瑞昔布超前镇痛有效缓解妇科门诊手术术后疼痛的随机对照研究

Parecoxib pretreatment effectively relieved pain after ambulatory gynecological surgery: a randomized controlled trial

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