SecA inhibitors: next generation antimicrobials

doi:10.5246/jcps.2012.06.067

SecA inhibitors: next generation antimicrobials

Weixuan Chen, Arpana Chaudhary, Jianmei Cui, Jinshan Jin, Yinghsin Hsieh, Hsiuchin Yang, Yingju Huang, Phang C. Tai^*, Binghe Wang^*

Departments of Chemistry¹ and Biology², Center for Diagnostics and Therapeutics, and Center for Biotechnology and Drug Design, Georgia State University, Atlanta, Georgia USA 30303

收稿日期:2012-08-26 修回日期:2012-09-26 出版日期:2012-10-25 发布日期:2012-10-25
通讯作者: Phang C. Tai*, Binghe Wang*

SecA inhibitors: next generation antimicrobials

Weixuan Chen, Arpana Chaudhary, Jianmei Cui, Jinshan Jin, Yinghsin Hsieh, Hsiuchin Yang, Yingju Huang, Phang C. Tai^*, Binghe Wang^*

Departments of Chemistry¹ and Biology², Center for Diagnostics and Therapeutics, and Center for Biotechnology and Drug Design, Georgia State University, Atlanta, Georgia USA 30303

Received:2012-08-26 Revised:2012-09-26 Online:2012-10-25 Published:2012-10-25
Contact: Phang C. Tai*, Binghe Wang*

摘要/Abstract

摘要：

Health problems caused by bacterial infection have become a major public health concern in recent years due to the widespread emergence of drug-resistant bacterial strains. Therefore, the need for the development of new types of antimicrobial agents, especially those with a novel mechanism of action, is urgent. SecA, one of the key components of the secretion (Sec) pathway, is a new promising target for antimicrobial agent design. In recent years, promising leads targeting SecA have been identified and the feasibility of developing antimicrobial agents through the inhibition of SecA has been demonstrated. We hope this review will help stimulate more research in this area so that new antimicrobials can be obtained by targeting SecA.

关键词: SecA inhibitors, Antimicrobials, Natural sources, Small-molecule inhibitors

Abstract:

Key words: SecA inhibitors, Antimicrobials, Natural sources, Small-molecule inhibitors

中图分类号:

R916

Supporting:

^*Corresponding author.
PCT. Tel.: +1-404-413-5303; Fax: +1-404-413-5301; E-mail: biopct@gsu.edu;
BW. Tel.: +1-404-413-5544; Fax: +1-404-413-5543; E-mail: wang@gsu.edu

Dedicated to Professor Lihe Zhang on the occasion of his 75^th birthday

Weixuan Chen, Arpana Chaudhary, Jianmei Cui, Jinshan Jin, Yinghsin Hsieh, Hsiuchin Yang, Yingju Huang, Phang C. Tai^*, Binghe Wang^* . SecA inhibitors: next generation antimicrobials [J]. , DOI: 10.5246/jcps.2012.06.067.

参考文献

[1] Payne, D.J. Science. 2008, 321, 1644-1645.
[2] Mori, H.; Ito, K. Trends Microbiol. 2001, 9, 494-500.
[3] Vrontou, E.; Economou, A. Biochim. Biophys. Acta. 2004, 1694, 67-80.
[4] Manting, E.H.; Driessen, A.J.M. Mol. Microbiol. 2000, 37, 226-238.
[5] Berks, B.C.; Sargent, F.; Palmer, T. Mol. Microliol. 2000, 35, 260-274.
[6] Luirink, J.; Sinning, I. Biochim. Biophys. Acta. 2004, 1694, 17-35.
[7] Park, S.; Liu, G.; Topping, T.B.; Cover, W.H.; Randall, L.L. Science. 1988, 239, 1033-1035.
[8] van Klompenburg, W.; Ridder, A.N.; van Raalte, A.L.; Killian, A.J.; von Heijne, G. FEBS Lett. 1997, 413, 109-114.
[9] Lill, R.; Dowhan, W.; Wickner, W. Cell. 1990, 60, 271-280.
[10] Gierasch, L.M. Biochemistry. 1989, 28, 923-930.
[11] Claros, M.G.; Brunak, S.; von Heijne, G. Curr. Opin. Struct. Biol. 1997, 7, 394-398.
[12] Roosmalen, M.L.V.; Geukens, N.; Jongbloed, J.D.H.; Tjalsma, H.; Dubois, J.Y.F.; Bron, S.; van Dijl, J.M.; Anné, J. Biochim. Biophys. Acta. 2004, 1694, 279-297.
[13] Paetzel, M.; Dalbey, R.E.; Strynadka, N.C. Nature. 1998, 396, 186-190.
[14] Duguay, A.R.; Silhavy, T.J. Biochim. Biophys. Acta. 2004, 1694, 121-134.
[15] Segers, K.; Klaassen, H.; Economou, A.; Chaltin, P.; Anné, J. Anal. Biochem. 2011, 413, 90-96.
[16] Loew, O. Ber. Deut. Chem. Ges. 1891, 24, 2947-2953.
[17] Oliver, D.B.; Cabelli, R.J.; Dolan, K.M.; Jarosik, G.P. Proc. Natl. Acad. Sci. USA. 1990, 87, 8227-8231.
[18] Bowler, M.W.; Montgomery, M.G.; Leslie, A.G.; Walker, J.E. Proc. Natl. Acad. Sci. USA. 2006, 103, 8646-8649.
[19] Yoshikawa, S.; Shinzawa-Itoh, K.; Nakashima, R.; Yaono, R.; Yamashita, E.; Inoue, N.; Yao, M.; Fei, M.J.; Libeu, C.P.; Mizushima, T.; Yamaguchi, H.; Tomizaki, T.; Tsukihara, T. Science. 1998, 280, 1723-1729.
[20] Stoddard, B.L.; Ringe, D.; Petsko, G.A. Protein Eng. 1990, 4, 113-119.
[21] Yound, J.M.; Wang, J.H. J. Biol. Chem. 1971, 246, 2815-2821.
[22] Zaitsev, V.N.; Zaitseva, I.; Papiz, M.; Lindley, P.F. J. Biol. Inorg. Chem. 1999, 4, 579-587.
[23] Sugie, Y.; Inagaki, S.; Kato, Y.; Nishida, H.; Pang, C.H.; Saito, T.; Sakemi, S.; Dib-Hajj, F.; Mueller, J.P.; Sutcliffe, J.; Kojima, Y. J. Antibiot. 2002, 55, 25-29.
[24] Schobert, R.; Schlenk, A. Bioorg. Med. Chem. 2008, 16, 4203-4221.
[25] Forsyth, R.A.; Haselbeck, R.J.; Ohlsen, K.L.; Yamamoto, R.T.; Xu, H.; Trawick, J.D.; Wall, D.; Wang, L.; Brown-Driver, V.; Froelich, J.M.; King, P.; McCarthy, M.; Malone, C.; Misiner, B.; Robbins, D.; Tan, Z.; Zhu, Z.Y.; Carr, G.; Mosca, D.A.; Zamudio, C.; Foulkes, J.G.; Zyskind, J.W. Mol. Microbiol. 2002, 43, 1387-1400.
[26] Parish, C.A.; Cruz, M.D.; Smith, S.K.; Zink, D.; Baxter, J.; Tucker-Samaras, S.; Collado, J.; Platas, G.; Bills, G.; Díez, M.T.; Vicente, F.; Peláez, F.; Wilson, K. J. Nat. Prod. 2008, 72, 59-62.
[27] Boros, C.; Dix, A.; Katz, B.; Vasina, Y.; Pearce, C. J. Antibiot. 2003, 56, 862-865.
[28] Alksne, L.E.; Burgio, P.; Hu, W.; Feld, B.; Singh, M.P.; Tuckman, M.; Petersen, P.J.; Labthavikul, P.; McGlynn, M.; Barbieri, L.; McDonald, L.; Bradford, P.; Dushin, R.G.; Rothstein, D.; Projan, S.J. Antimicrob. Agents Chemother. 2000, 44, 1418-1427.
[29] Jang, M.Y.; Jonghe, S.D.; Segers, K.; Anné, J.; Herdewijn, P. Bioorg. Med. Chem. 2011, 19, 702-714.
[30] Li, M.; Huang, Y.J.; Tai, P.C.; Wang, B. Biochem. Biophys. Res. Commun. 2008, 368, 839-845.
[31] Chen, W.; Huang, Y.J.; Gundala, S.R.; Yang, H.; Li, M.; Tai, P.C.; Wang, B. Bioorg. Med. Chem. 2010, 18, 1617-1625.
[32] Huang, Y.J.; Wang, H.; Gao, F.B.; Li, M.; Yang, H.; Wang, B.; Tai, P.C. ChemMedChem. 2012, 7, 571-577.
[33] Stephens, C.; Shapiro, L. Chem. Biol. 1997, 4, 637-641.
[34] Ni, N.L.M.; Chou, H.T.; Choudhary, G.; Lu, C.D.; Tai, P.C.; Wang, B. Chem. Biol. Drug Design. 2009, 74, 51-56.
[35] Surette, M.G.; Bassler, B.L. Proc. Natl. Acad. Sci. USA. 1998, 95, 7046-7050.
[36] Surette, M.G.; Miller, M.B.; Bassler, B.L. Proc. Natl. Acad. Sci. USA. 1999, 96, 1639-1644.
[37] Waters, C.M.; Bassler, B.L. Annu. Rev. Cell Dev. Biol. 2005, 21, 319-346.

SecA inhibitors: next generation antimicrobials

SecA inhibitors: next generation antimicrobials

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