Butyrolactones, inhibitors of 5-lipoxygenase from fungal metabolites

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Butyrolactones, inhibitors of 5-lipoxygenase from fungal metabolites

Fu-Sheng Wang, Ai-Bing Ke, Jing-Tong Zhu, Ye-Ying Li, Xin-Hua Lu, Zhi-Hui Zheng, Hua Zhang, Ying Ma, Xiao Ren, Ya-Ting Wang, Bao-Hua Zhao^*

1. Department of Life Science, Hebei Normal University, Shijiazhuang 050015, China
2. New Drug R & D Center of the North China Pharmaceutical Group Corporation, Shijiazhuang 050015, China

Received:2010-02-03 Revised:2010-06-10 Online:2010-07-15 Published:2010-07-15
Contact: Bao-Hua Zhao*

Abstract

Abstract:

In our ongoing search for new inhibitors of 5-lipoxygenase (5-LOX) from microbial resources, Aspergillus F06Z-509 was found to produce active components. Three active compounds named F06Z-509-A, B and C were obtained and identified as butyrolactone II, I and III by NMR and MS data analyses. They showed inhibitory activity against 5-LOX with IC50 of 21.43, 22.51 and 11.83 μg/mL, respectively. Butyrolactones are shown to be inhibitors of 5-LOX for the first time.

Key words: 5-Lipoxygenase inhibitors, Butyrolactones, Fungal metabolites

CLC Number:

R284

Supporting:

Fu-Sheng Wang, Ai-Bing Ke, Jing-Tong Zhu, Ye-Ying Li, Xin-Hua Lu, Zhi-Hui Zheng, Hua Zhang, Ying Ma, Xiao Ren, Ya-Ting Wang, Bao-Hua Zhao^*. Butyrolactones, inhibitors of 5-lipoxygenase from fungal metabolites [J]. .

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Butyrolactones, inhibitors of 5-lipoxygenase from fungal metabolites

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