Liposoluble chemical constituents from the fibrous root of Ophiopogon japonicas

Abstract

Abstract:

We investigated the chemical constituents of the fibrous root of Ophiopogon japonicus and their cytotoxicities against Hela and Hep2 cells. Ten compounds were purified by various chromatographic techniques. Their structures were identified as 2'-hydroxylophiopogonone A (1), 5,8-dimethoxy-6-methyl-7-hydroxy-3-(2'-hydroxy-4'-methoxybenzyl) chroman-4-one (2), 5,7-dihydroxy-6,8-dimethyl-3-(4'-hydroxybenzyl) chroman-4-one (3), 7,4'-dihydroxy-5-methoxyflavanone (4), N-trans-coumaroyltyramine(5), N-trans-coumaroyloctopamine (6), N-trans-feruloyltyramine (7), 4-hydroxycinnamic acid (8), caffeic acid (9), and ferulic acid (10) on the basis of spectroscopic analyses. Compounds 4, 6, 7, 9, 10 were obtained from this genus for the first time. The cytotoxic activities of 1, 2, 4, 5, 6, 7, 9 and 10 against Hela and Hep2 cells are described.

Key words: Liliaceae, Liliaceae, Ophiopogon japonicus, Ophiopogon japonicus, Fibrous root, Fibrous root, Chemical constituents, Chemical constituents, Cytotoxicity, Cytotoxicity

CLC Number:

R284.1

Supporting:

Chang-Ling Duan^1,2, Yu Jiang³, Yong Jiang¹, Cheng-Ren Lin², Jian-Xun Liu², Peng-Fei Tu^1* . Liposoluble chemical constituents from the fibrous root of Ophiopogon japonicas [J]. .

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Liposoluble chemical constituents from the fibrous root of Ophiopogon japonicas

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