Recent progress of natural products in tumor prevention and treatment by regulating the reactive oxygen species level

doi:10.5246/jcps.2021.06.035

Abstract

Abstract:

Reactive oxygen species (ROS) is widespread in living organisms. Under normal conditions, ROS remains at low concentrations to maintain normal cell function. Studies have found that the abnormal elevation of ROS levels in normal tissues is an important mechanism underlying the tumorigenesis. However, high concentrations of ROS also have toxic, genotoxic, and even apoptotic effects on tumor cells. ROS has become one of the important targets for cancer prevention and treatment. Natural products widely exist in nature and have a wide range of pharmacological activities, which can affect the function of ROS. In the present study, we reviewed the research progress of natural products in tumor prevention and treatment by regulating ROS level in recent years.

Key words: Natural products, Antitumor therapy, ROS, Level

Supporting:

Zixiang Wang, Yifan Zhang, Wangchun Du, Qunli Chen, Hong Yao, Mei Zhao. Recent progress of natural products in tumor prevention and treatment by regulating the reactive oxygen species level[J]. Journal of Chinese Pharmaceutical Sciences, 2021, 30(6): 455-467.

Figures/Tables 5

References 67

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