Oyster peptide ameliorates hepatic fibrosis through the NF-κB/iNOS signaling pathway

doi:10.5246/jcps.2023.06.037

Abstract

Abstract:

In the present study, we found that oyster peptide (OP) could ameliorate hepatic fibrosis through the NF-κB/iNOS signaling pathway. A total of 50 male Sprague-Dawley rats were randomly divided into five groups by the random digital table method: control group, model group, low-dose (0.5 g/kg) OP group, medium-dose (1.0 g/kg) OP group, and high-dose (2.0 g/kg) OP group, with 10 rats in each group. The rat model of hepatic fibrosis was established by subcutaneous injection of 50% carbon tetrachloride (CCl₄). In OP therapy groups, the expressions of collagen I, collagen III, and TGF-β1 in the liver with CCl₄-induced hepatic fibrosis were significantly lower than those in the model group (P < 0.05). OP could down-regulate the expressions of NF-κB and iNOS in the liver tissue of rats with hepatic fibrosis. Collectively, OP ameliorated hepatic fibrosis, possibly through the NF-κB/iNOS signaling pathway.

Key words: Hepatic fibrosis, Oyster peptide, NF-κB, Inducible nitric oxide synthase

Supporting:

Kaixiang Deng, Jingzhou Peng, Meiquan Zhang, Huijuan Lin, Xiaohua Wang, Daoxing He, Junming Zhu, Mingguang Chen, Jin Huang. Oyster peptide ameliorates hepatic fibrosis through the NF-κB/iNOS signaling pathway[J]. Journal of Chinese Pharmaceutical Sciences, 2023, 32(6): 435-445.

Figures/Tables 6

References 27

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