Cardiovascular protective effects of astragaloside IV

doi:10.5246/jcps.2013.03.031

Abstract

Abstract:

Astragali Radix has been widely used in traditional Chinese medicine for centuries, especially for the treatment of cardiovascular diseases. Astragaloside IV (AST IV), one of the main active ingredients in Astragali Radix, is involved in various functions, including vasodilating effect, protecting the vascular endothelial cells, anti-inflammatory effect, antivirus effect, positive inotropism and so on. These functions are attributed to the ability of AST IV in scavenging oxygen free radicals, the regulation of calcium homeostasis, its anti-oxidative effect and prevention of mitochondrial damage. Astragaloside IV has been effectively used to treat coronary artery disease, heart failure, viral myocarditis, hypertension and other cardiovascular diseases. Its cardiovascular protective effects and mechanisms are worth studying.

Key words: Astragaloside IV, Cardiovascular, Protective effect, Mechanism

CLC Number:

Supporting:

Shuai Liu, Jinguo Zhang^*. Cardiovascular protective effects of astragaloside IV [J]. , DOI: 10.5246/jcps.2013.03.031.

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