http://jcps.bjmu.edu.cn

Journal of Chinese Pharmaceutical Sciences ›› 2019, Vol. 28 ›› Issue (10): 699-703.DOI: 10.5246/jcps.2019.10.066

• Original articles • Previous Articles     Next Articles

A concise total synthesis of secoisolariciresinol

Jiuzhou Guo, Yanxing Jia*   

  1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
  • Received:2019-05-05 Revised:2019-09-03 Online:2019-10-31 Published:2018-11-30
  • Contact: Tel.: +86-10-82805166, E-mail: yxjia@bjmu.edu.cn
  • Supported by:

    The Drug Innovation Major Project (Grant No. 2018ZX09711-001-005-005).

Abstract:

A concise total synthesis of (R,R)-secoisolariciresinol was achieved in four steps, featuring a biomimetic β-β’ radical coupling of two dihydroferulic acid derivatives. The conversion of secoisolariciresinol to other related lignans was ongoing.

Key words: Secoisolariciresinol, Lignan, Total synthesis, Biomimetic synthesis

CLC Number: 

Supporting: