Sini Powder extract produces antidepressant-like effects in a chronic social defeat stress model of depression in tree shrews

doi:10.5246/jcps.2016.06.051

Journal of Chinese Pharmaceutical Sciences ›› 2016, Vol. 25 ›› Issue (6): 458-465.DOI: 10.5246/jcps.2016.06.051

• Original articles • Previous Articles Next Articles

Sini Powder extract produces antidepressant-like effects in a chronic social defeat stress model of depression in tree shrews

Shanshan Wei¹, Hejin Yang², Jiawen Huang², Xueping Lu², Lingfang Peng², Qingguo Wang^1*

1. School of Basic Medicine, Beijing University of Chinese Medicine, Beijing, 100029, China
2. Department of Drug Screening, Yunnan Institute of Materia Medica, Kunming, 650111, China

Received:2016-02-17 Revised:2016-03-27 Online:2016-06-29 Published:2016-04-16
Contact: Tel.: +86-010-64286727, Fax: +86-010-64213817, E-mail: wangqg8558@sina.com
Supported by:
National Basic Research Program of China (Grant No. 2011CB505100) funded by the Ministry of Science and Technology of China.

Abstract

Abstract:

Sini Power (SP) is a famed traditional Chinese formula that has long been used to treat depression. Here, we investigated the effects and possible mechanisms of SP extract on an established model of depression: chronic stressed tree shrew, which mimics the human condition of social stress. The animals were divided into 4 groups. Except for the naïve group, the other animalswere subjected to daily social defeat stress for 5 weeks, and during the last 4 weeks treated with SP extract (3.6 g/kg/d), fluoxetine (15 mg/kg/d), and vehicle, respectively. The results showed that SP extract could reverse body weight loss to a certain extent and reduce the levels of urine/serum cortisol that were initially increased by chronic social defeat. In addition, SP extract increased hippocampus norepinephrine concentrations. Our data suggested that SP extract had positive effects on the main depression symptoms in the chronic stressed tree shrew model and that it may be used to help control hypothalamic-pituitary-adrenal axis hyperactivity.

Key words: Chronic stress, Tree shrews, Social defeat, Sini Powder extract, Hypothalamic-pituitary-adrenal axis

CLC Number:

R284

Supporting:

Shanshan Wei, Hejin Yang, Jiawen Huang, Xueping Lu, Lingfang Peng, Qingguo Wang. Sini Powder extract produces antidepressant-like effects in a chronic social defeat stress model of depression in tree shrews[J]. Journal of Chinese Pharmaceutical Sciences, 2016, 25(6): 458-465.

References

[1] Marcus, M.; Yasamy, M.T.; van Ommeren, M.; Chisholm, D.; Saxena, S. Depression: A global public health concern. WHO. 2012, 1, 6-8. This article can be found online at http://www.who.int/mental_health/management/depression/en/
[2] D’Aquila, P.S.; Coventry, T.; Brain, P.F.; Willner, P. Behav. Pharmacol. 1995, 6, 12-13.
[3] Åslund, C.; Leppert, J.; Starrin, B.; Nilsson, K.W. Arch. Pediatr. Adolesc. Med. 2009, 163, 55-60.
[4] Fan, Y.; Huang, Z.Y.; Cao, C.C.; Chen, C.S.; Chen, Y.X.; Fan, D.D.; Jiang, X.T. Nat. Commun. 2013, 4, 1426.
[5] Kampen, M.V.; Kramer, M.; Hiemke, C.; Flügge, G.; Fuchs, E. Stress. 2002, 5, 37-46.
[6] Fuchs, E.; Jöhren, O.; Flügge, G. Psychoneuroendocrinogy. 1993, 18, 557-565.
[7] Fuchs, E.; Jöhren, O.; Flügge, G. Pharmacol. Biochem. Behav. 1996, 54, 219-228.
[8] Jöhren, O.; Flügge, G.; Fuchs, E. Cell Mol. Neurobiol. 1994, 14, 281-296.
[9] Fuchs, E.; Flügge, G. Pharmacol. Biochem. Behav. 2002, 73, 247-258.
[10] Xie, Z.; Wang, X. Chin. J. Inf. TCM. 2005, 12, 8-9.
[11] Huang, N.; Lin, Y.; Xia, H. Chin. New Drugs J. 2013, 45, 16-18.
[12] Dou, W.; Wang, Q. Henan Chin. Med. 2015, 35, 1760-1761.
[13] Yehuda, R.; Flory, J.D.; Bierer, L.M.; Henn-Haase, C.; Lehrner, A.; Desarnaud, F.; Makotkine, I.; Daskalakis, N.P., Marmar, C.R.; Meaney, M.J. Biol. Psychiatry. 2015, 77, 356-364.
[14] Shi, R.; Wang, Q.; Liu, B.; Chang, H.; Li, J. Patent CN 1416880A, China, 2003.
[15] Li, Y.; Sun, Y.; Ma, X.; Xue, X.; Zhang, W.; Wu, Z. J. Tradit. Chin. Med. 2013, 33, 674-681.
[16] Wu, T. master, thesis, Beijing University of Chinese Medicine. 2011.
[17] Czéh, B.; Simon, M.; Schmelting, B.; Hiemke, C.; Fuchs, E. Neuropsychopharmacol. 2006, 31, 1616-1626.
[18] Wei, S.; Lu, X.; Peng, L.; Qu, H.; Sun, Y,; Wang, Q. Chin. Pharm. 2014, 25, 2323-2325.
[19] Fuchs, E.; Kramer, M.; Hermes, B.; Netter, P.; Hiemke, C. Pharmacol. Biochem. Behav. 1996, 54, 219-228.
[20] American Psychiatric Pub. 2013. This article can be found online at http://www.lswo2014.org/StanMcCrackenDSMV
[21] Elhwuegi, A.S. Prog Neuro-Psychoph, 2004, 28, 435-451.

Sini Powder extract produces antidepressant-like effects in a chronic social defeat stress model of depression in tree shrews

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	Jinhui Shi, Ruiyue Li, Siyu Yang, Hongmei Zhang. Phytochemistry, biological properties and quality control of Chuanxiong Rhizoma: a review [J]. Journal of Chinese Pharmaceutical Sciences, 2020, 29(11): 755-779.
[2]	Yawen Wang, Xiaofeng Duan, Xiaoxiao Cheng, Miaoxin Zhang, Li Li, Ding Zhao. The regulatory effects of mulberry leaf and its extract on intestinal function [J]. Journal of Chinese Pharmaceutical Sciences, 2020, 29(11): 780-792.
[3]	Lulu Xu, Zhanpeng Shang, Yue Chai, Yang Zhang, Rong Yu, Min Ye, Xue Qiao. Detection of minor constituents in TongMai Granules using NP×RP off-line two-dimensional liquid chromatography coupled with orbitrap mass spectrometry [J]. Journal of Chinese Pharmaceutical Sciences, 2020, 29(11): 793-803.
[4]	Fangfang Xu, Biao Sun, Xiaoqi Zhang, Bo Liu. Flavonoid C-glycosides from the seeds of Hovenia dulcis Thunb. [J]. Journal of Chinese Pharmaceutical Sciences, 2020, 29(11): 813-818.
[5]	Eric Wei Chiang Chan, Oi Yoon Michelle Soo, Yong Hui Tan, Siu Kuin Wong, Hung Tuck Chan. Nobiletin and tangeretin (citrus polymethoxyflavones): an overview on their chemistry, pharmacology and cytotoxic activities against breast cancer [J]. Journal of Chinese Pharmaceutical Sciences, 2020, 29(7): 443-454.
[6]	Huinan Wang, Jingzhen Zhang, Yuexin Cui, Siyu Wang, Hui Gao, Yao Zhang, Xinjie Wang, Ziye Yang, Mengyu Chen, Peihua Wang, Guimei Zhang, Yingzi Wang, Chao Zhang. Chemical comparison of Semen Euphorbiae and Semen Euphorbiae Pulveratum by UPLC-Q-TOF/MS coupled with multivariate statistical techniques [J]. Journal of Chinese Pharmaceutical Sciences, 2020, 29(7): 470-479.
[7]	Yunling Xu, Yuji Wang, Shiping Jiang, Tingting Cai, Nannan Wang, Xia Liu, Wanping Zhu. Chemical constituents from the fruit of Schisandra Chinensis [J]. Journal of Chinese Pharmaceutical Sciences, 2020, 29(7): 480-486.
[8]	Jing Chen, Li Cheng, Fuqian Wang, Xuanbin Wang, Yonghui Zhang, Xincai Hao. Chemical constituents from Trichosanthes cucumeroides [J]. Journal of Chinese Pharmaceutical Sciences, 2020, 29(6): 431-438.
[9]	Jingran Fan, Zeyuan Dong, Yi Kuang, Yanxia Zhou, Xue Qiao, Min Ye. Chemical constituents of the aerial parts of Glycyrrhiza uralensis and their inhibitory activities against PTP1B and α-glucosidase [J]. Journal of Chinese Pharmaceutical Sciences, 2020, 29(5): 305-313.
[10]	Cui Wu, Liang Xu, Bo Xu, Zhuojun Li, Zhimao Chao. Correlation between 5-hydroxymethylfurfural content and color of Rehmanniae Radix and Rehmanniae Radix Praeparata [J]. Journal of Chinese Pharmaceutical Sciences, 2020, 29(5): 314-321.
[11]	Makhmur Ahmad, Mohammad Rashid, Babar Ali, Shamshir Khan, Naseem Akhtar, Mohd Faiyaz Khan, Bibhu Prasad Panda. Immobilization of β-glucuronidase: biocatalysis of glycyrrhizin to 18β-glycyrrhetinic acid and in-silico lead finding [J]. Journal of Chinese Pharmaceutical Sciences, 2020, 29(5): 333-340.
[12]	Jin Huang, Lingxin Yang, Ning Yang, Bowen Yuan, Hao Zhang, Mengyue Wang. The inhibitory activities of Urtica fissa to BPH [J]. Journal of Chinese Pharmaceutical Sciences, 2020, 29(4): 236-243.
[13]	Jimei Liu, Minghua Chen, Ridao Chen, Kebo Xie, Dawei Chen, Shuyi Si, Jungui Dai. Three new compounds from endophytic fungus Periconia sp. F-31 [J]. Journal of Chinese Pharmaceutical Sciences, 2020, 29(4): 244-251.
[14]	Hongshuai Yang, Qiuyi Liu, Weidong Yin, Manjiang Xie, Xiang Ji, Shuangyu Shao, Hong Liang, Pengfei Tu, Qingying Zhang. Identification and discrimination of Ziziphi Spinosae Semen and Ziziphi Mauritianae Semen based on HPLC fingerprint analysis [J]. Journal of Chinese Pharmaceutical Sciences, 2020, 29(4): 252-259.
[15]	Xiaoxia Liang, Cheng Xiong, Yingying Gao, Qiaojia Fan. Antioxidantive activities and gastrodin determination of extracts of endophytic fungi isolated from Gastrodia elata Bl. [J]. Journal of Chinese Pharmaceutical Sciences, 2020, 29(3): 206-213.