Regulatory effects of coenzyme Q10 on the immunological activity of mice

doi:10.5246/jcps.2016.06.050

Abstract

Abstract:

To examine how coenzyme Q10 (CoQ₁₀)regulates immunity, experiments using low, middle and high doses of CoQ₁₀were conducted in mice to confirm its non-toxicity and non-genotoxicity. Delayed type hypersensitivity (DTH) and MTT assays were used to to examine various lymphocyte transformations, the proliferation of antibody-producing cells, the phagocytotsis activity of macrophages, and the activity of nature killer cell (NK). High-dose (0.50 g/kg.bw) CoQ₁₀ increased DTH levels and promoted the proliferation of antibody-producing cells and levels of red blood cell hemolysis. Medium and high doses enhanced the phagocytic ratio of macrophages but didnot influence other indexes. These results showed that the applied CoQ₁₀did not exhibit any toxicity or genotoxicity, and CoQ₁₀can actually improve immunologic function in mice.

Key words: Coenzyme Q10, Toxicity, Genotoxicity, Immune function, Health

CLC Number:

R962

Supporting:

Yingjie Xu, Li Shuai, Jiang Hu, Delin Duan. Regulatory effects of coenzyme Q10 on the immunological activity of mice[J]. Journal of Chinese Pharmaceutical Sciences, 2016, 25(6): 448-457.

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